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I'm not too sure on that. Those drugs are very inexpensive and hardly profitable. And some patients probably often spend a similar amount on supplements, where pharmaceuticals loose out on profit. I think an expensive biologic (like Efgartigimod which also requires regular use) would be much...

In reference to ME/CFS that however seems to make little sense to me as there's no drugs to treat anything and as such also no customers. I've never found the "lifetime customers" a strong argument in the general situation, because adressing a root cause could equally produce a lifetime...

Thanks for working on this and in particular thank you for commenting here and by doing so engaging with patients and researchers @DMissa. Thanks for providing some cohort data. Unfortunately, I didn't see anything on comorbidties, was this not examined? Do you know if the cohorts were BMI...

Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis/chronic fatigue syndrome Significance Myalgic encephalomyelitis/chronic fatigue syndrome (ME) is a serious disabling chronic illness that lacks FDA-approved therapies. Comprehensive...

Precisely, which is why I think there is no need to use this survey for those purposes.

I wouldn't be too sure about that. From what I understand the survey was largely shared amongst "Twitter friends" so presumably people who often have a similar opinion as you and I think quite a few in that sphere would have known about the history of ME/CFS and GET. Since quite a few countries...

Interesting, that one can do that in a systematic review, i.e. use a system such as GRADE, but then also move outside of said system and judge certain studies according to your own criteria without specifying what these criteria even are, since "plausibility assessment" wouldn't seem to be part...

Now published as Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19.

A bit like saying: The only thing that can treat Alzheimers is moonstones. The conclusion was made on subjective outcome measures. In fact when assessing patients post moonstone therapy to examine whether they had Alzheimers after treatment most couldn't remember that they did, suggesting a high...

Haven't looked at it yet, but from what I recall there have been at least 2 HBOT RCTs by the same group on LC. Will have to look into why one was included and the other excluded.

I'm also curious how they rated the synbiotic study (thread here) as lower quality of evidence. Not that I believe it has any value in the treatment of LC (the authors didn't report any meaningful data and the LC classifications were nonsense), but it was at least a double blind placebo...

I was trying to say that, that in itself would still be a theory, because you'll unfortunately never be able to prove that it was in fact cumin that had that effect. A member of the international association for scuba-diving enthusiasts might argue that it was in fact entirely psychological...

But does a subgroup even exist? I used to know people without any medical condition that hadn't been ill for over 10 years and others that were sick every second month. For a subgroup of ME/CFS patients to even exist you'd have to show that the percentage of these people is higher than in the...

If these differences would be representative of LC, other studies would have already picked them up. So why do they appear here? Is this an issue for a subcohort and they managed to pick out the right cohort? Perhaps a cohort with autoimmune disorders, since the authors don't seem to report the...

I know a prominent LC researcher changed their opinion on ME/CFS on the basis of their own research results. I think for many other researchers in the LC field that will be rather similar and sometimes these will convice their colleagues of the same. I find that rather problematic, since they...

Precisely. My understanding of ME/CFS and PEM is that everybody can reliably produce PEM if they wanted to. They will typically often produce it without wanting to, to be able to do basic activities that make life worthwhile or simply necessary activities to stay alive. What they cannot do is...

You're right!

I forgot about this one (even though I read about it yesterday), but glancing over what is written it doesn't seem to be one of those trials launched towards the beginning of the pandemic to address acute Covid, but seems rather Long-Covid specific? From what I remember the trials looking at...

In regards to BCG, there were an abundance of different trials on different BCG formulations with tens of thousands of participants to see whether there is an impact on acute Covid (I don't think any had a Long-Covid follow-up). At the beginning of the pandemic there was the speculation that...

Do you mean people that haven't pushed themselves beyond some threshold to experience PEM for some time and upon pushing themselves notice that they don't experience PEM at all anymore or people that haven't pushed themselves beyond some threshold and then notice that their threshold is actually...