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Here's an interview from last year with the first author, Michael Sneller, that definitely shows some concerning attitudes and ideas. He also seems to favour PTSD as an explanation for post-Ebola symptoms in his previous work (see Discussion). Here he is on NPR suggesting physical therapy and...

They report two different things, which people are mixing up: People with Long Covid are more likely to have "anxiety" or "depression" according to their questionnaires, which may be the questionnaires capturing physiological LC symptoms as mental health symptoms, actual mental health symptoms...

Does anyone know if DecodeME is collecting data from participants on family members with ME? Seems like it would be useful to rule in/out genetic factors in the subgroup of people with ME who also have family members with ME, just in case we're dealing with more than one illness. I guess if a...

Pretty big percentage of people with some kind of post-Covid symptom (22%), considering their study design likely underestimates prevalence for a few reasons: People who had an asymptomatic infection or an otherwise undiagnosed infection would have ended up in their control group. Subtracting...

Accompanying editorial, which highlights that the study didn't look at PEM and that the anxiety found may actually be autonomic issues.

From the Discussion: "For participants with PASC, an extensive diagnostic evaluation failed to reveal a cause of reported symptoms in most cases. Exploratory studies did not show evidence of abnormal systemic immune activation or persistent viral infection in participants with PASC. The...

Abstract Background: A substantial proportion of persons who develop COVID-19 report persistent symptoms after acute illness. Various pathophysiologic mechanisms have been implicated in the pathogenesis of postacute sequelae of SARS-CoV-2 infection (PASC). Objective: To characterize medical...

My impression is that ME symptoms vary quite considerably. It would be interesting to study to see if people with suspected post-EBV infection ME onset, for instance, are at all different from a group with a different suspected onset. It might be very hard to separate two groups in this way, but...

There seem to be quite a few people who describe a series of colds or other infections or a period of poor health before they become seriously ill. I don't think it is unreasonable to say that maybe people can have ME very mildly and then get significantly worse. In that case, the trigger...

My own experience suggests a long delay between some event, probably an infection, and becoming significantly ill. As a teenager, there was something off for about a year before I suddenly became ill. Basically, it felt like I had recurring colds plus very mild PEM (I could do fine in a...

And of course, the mechanism here is that the PON1 variant reduces the rate at which sarin is metabolized (so presumably increases the exposure to low-level sarin in the blood because it is cleared significantly slower), which doesn't have anything to do with ME in general. So you wouldn't...

Nope, they didn't find any association between ME and PON1, but of course that study was tiny.

That's interesting. Looks like they are basically doing what they did in serum, as described in the paper, in mice now: "They gave the mice a compound , an mTOR activator and autophagy inhibitor that inactivates a protein called ATG13 which activates two mytokines called IL-6 and RANTES...

Key Points VWF(Ag):ADAMTS13 ratio ≥1.5 was evident in 28% of PCS cohort 55% of patients with impaired exercise capacity had a raised VWF(Ag):ADAMTS13 ratio ≥1.5 (OR 4) Post-COVID syndrome (PCS) or Long-COVID is an increasingly recognised complication of acute SARS-CoV-2 infection...

If his claim (that they can distinguish people with ME, people with FM, people with ME & FM, and healthy controls) pans out this would be pretty significant. The test obviously isn't super practical for widespread use, but any kind of test is better than no test (and it's certainly much better...

Oh no, that looks pretty bad. CBC is reporting: The most common [symptoms], according to PHAC, are fatigue, memory problems, anxiety, depression and even post-traumatic stress disorder. and "Long COVID symptoms can be quite broad and non-specific, and so depending on the questions and the...

The new ONS report on Long Covid after Delta versus BA.1 versus BA.2 first infections for double and triple vaccinated people is depressing. Basically, for triple-vaccinated people roughly 8% reported LC 4-8 weeks after infection, no matter which variant (BA.2 is about 9%, BA.1 and Delta 8%)...

I asked Avik Roy about the protein aggregation and he does think it is related to the LC microclots findings. This was a pretty strong finding, with a clear difference between the 7 patients and 7 controls in the rate of protein aggregation.

It looks like a significant part of the study was only done on the cohort that was 70% hospitalized and 30% ICU. It's not clear which parts included which cohorts (the EBV part, for instance, was just in the first cohort). The second cohort was only 10% hospitalized and reported significantly...

A couple things jump out about this: No adjustment for vaccination status (they acknowledge this as a shortcoming due to insufficient numbers). But you would think there may be a significant correlation between worries about losing your job, worries about not having enough to eat, worries about...