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    IDO2 gene mutations - SNPs

    I have a v4 23andme chip data file and it reports my rs10109853 IDO2 variants.
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    Virios Therapeutics - biotech company with anti-viral therapies for post-infection syndromes

    Here is the phase 2b clinical Trial info from clinical trials.gov: https://clinicaltrials.gov/ct2/show/NCT04748705?term=Imc-1&draw=2&rank=2
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    Virios Therapeutics - biotech company with anti-viral therapies for post-infection syndromes

    This is the company begun from Skip Pridgen's protocols. He is on the board of Directors: William L. Pridgen, M.D William L. Pridgen, M.D. is our founder and has been a director since 2018. Dr. Pridgen is a board-certified surgeon practicing with Tuscaloosa Surgical Associates, P.C. in...
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    Technology Feature Published: 28 April 2021 Scientists set out to connect the dots on long COVID (Nature article)

    interesting article. Thanks for posting. any reponses to this quote from Dr. Nath? …..Nath has heard that some people suffering from long COVID report feeling better upon vaccination. “This is known to occur in other diseases,” he says. For example, people with ME/CFS will report feeling...
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    Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain, Md Shafiqur Rahman, et al, 2020

    here is their decision tree for Selection of case and controls. Note the exclusion criterea.
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    Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain, Md Shafiqur Rahman, et al, 2020

    I found the “Discussion“ section to be quite interesting and intriguing. plenty of fodder for speculation. I would like to hear from people about what the authors have to say.
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    Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain, Md Shafiqur Rahman, et al, 2020

    Abstract Background and Objectives Chronic widespread musculoskeletal pain (CWP) is a symptom of fibromyalgia and a complex trait with poorly understood pathogenesis. CWP is heritable (48-54%), but its genetic architecture is unknown and candidate gene studies have produced inconsistent results...
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    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    I was listening to the September 12 podcast (TWIV 663) of “this week in virology“ and Dr. Racanciello said he recently visited Ian Lipkin, who was infected with covid-19 this spring, and Dr. Lipkin said that he loses his breath if he walks up a mild incline. sad to hear. I thought it was an...
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    Pain catastrophizing is associated with the Val66Met polymorphism of the brain-derived neurotrophic factor in fibromyalgia, da Silveira Alves , 2020

    abstract, etc: https://pubmed.ncbi.nlm.nih.gov/32736598/ open access: https://advancesinrheumatology.biomedcentral.com/articles/10.1186/s42358-020-00141-9 here is their conclusion...
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    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    I was listening to TWIV #645 and about 3:45 into the podcast Vincent Racaniello says that he recently spoke with Ian Lipkin (who had Covid back in the March timeframe) and asked him if he had any lingering symptoms and Dr. Lipkin said that "I am always exhausted“.
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    Post-Exertional Malaise - a discussion including defining and measuring PEM

    that is such a clear statement. Any idea what sort of measurements we might look at being useful?
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    David Fajgenbaum - Every Cure, non-profit for drug repurposing using AI

    I recently listened to this podcast with the author (a M.D.) of this book. Quite interesting with many parallels to people with a rare or poorly diagnosed illness. The author has Castleman disease. It even includes mention of mTor and sirolimus (rapamycin) as possibly helping these patients...
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    Coronavirus - worldwide spread and control

    This site was useful and user friendly for me. It lets you play with data and charts and graphs. https://ourworldindata.org/coronavirus
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    Shingles type pain...

    @Hell..hath..no..fury..., for a more specific term, look up the word “allodynia“. See if that fits. My father years ago had a simlilar pain and location as yours and he managed to achieve some relief with capsaicin cream..., but it hasn’t worked for me... best of luck to you.
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    Robert Naviaux' Lab - News - from 2019 onwards

    @Simon M, I was in that replication study and since it’s been like three years since I donated my blood, I emailed the Naviaux Lab to see if and when the Study will be published. I got a reply saying basically that they’re still massaging the data, but they plan to publish some day. I...
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    "Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia... van Campen et al, 2020

    I found it a readable paper for the layperson. The validity of the measurement techniques they used is way beyond me, but this statement struck me: They do not speculate on causation...
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    generic pharmaceutical fraud; book, “bottle of lies“.

    yeah, she said 90 percent of generic drugs sold in the United States are manufactured in Asia - India or China.
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    Rituximab and placebo response

    Jonathan, I have a question that stems from the Norwegian documentary on the rituximab studies that was posted in this forum: https://www.s4me.info/threads/left-out-norwegian-documentary-on-me.13393/ in this documentary one of the featured people is a woman who is obviously pretty close to...
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    generic pharmaceutical fraud; book, “bottle of lies“.

    I just finished listening to a podcast (2 hrs 45 Minutes) with Katherine Eban the author of the book, "Bottle of Lies"? it certainly captured my attention. The book is about fraud in the generic pharmaceutical manufacturing in Asian countries and the podcast focused a lot on one specific...
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