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I know exactly what you mean: especially with brain fog, if you get bombarded with too many undefined terms, it interrupts the natural flow of reading, and then you can lose interest, or you end up putting the article away for another time. It would be great to get feedback from your ME friends.

Thanks so much @Graham for reading it and giving feedback, it's much appreciated. That's a very good point. I'll add some info about timescales. I don't think the exact timescale of conversion to the non-cytolytic form is known, but in myocarditis it is certainly less than 28 days. In...

Yes, it sort of totally took over my life for the last two weeks! But there is so little accessible information out there about non-cytolytic enterovirus, even though several researchers think this viral aberration may be a major cause of ME/CFS.

Myositis often involves a chronic infection with the same aberrant form of enterovirus (non-cytolytic enterovirus) found in ME/CFS patients' muscles. So it could be your ME/CFS and myositis are caused by this same virus.

By the way, if anyone wants to have a go at adding a few pearls of their ME/CFS knowledge to MEpedia pages, it is pretty straightforward. You don't even need to set up an account (although it's better to do this in the long term). On any MEpedia article, just press the Edit button at the top of...

I thought I'd be the first to take advantage of this new MEpedia sub-fourm, by posting a link to a new MEpedia article I just completed today, which is found here: Non-cytolytic enterovirus — MEpedia article This MEpedia article is a (hopefully) accessible introduction to non-cytolytic...

Very interesting to see the coxsackievirus B results from Labcorp, Quest and ARUP compared side by side. I believe the LabCorp and Quest coxsackievirus B antibody assays use the complement fixation test (CFT) method, which is the most insensitive method. I love the way John Chia describes CFT...

Also, enterovirus has been linked to fatal heart attacks: a 2007 study found that 40% of people who died suddenly of a heart attack had evidence of an enterovirus infection in their heart tissues (specifically their endocardial or myocardial tissues). So the question is, did enterovirus...

That makes sense, because all the British studies that searched for enterovirus in the muscle tissue of ME/CFS patients used PCR to detect this virus, and PCR technology only became available in the late 1980s, and these British muscle biopsy studies using PCR were published in the 1990s. In...

Amazing, at least in those days they did ME/CFS testing thoroughly in the UK. But the pain of the muscle biopsy is the reason why Dr Chia pioneered using stomach biopsy instead, as this is painless. You find enterovirus in the stomach as well as the muscles, so may as well use the stomach for...

I would not have thought it was PCR, as I think that only became available in the late 1980s or later, but it seems you had a CVB antibody test, and possibly they may have tested your muscle tissues for the presence of enterovirus VP1 protein. Did you actually have the muscle biopsy mentioned...

A possible explanation for the above contradiction: the answer may relate to the fact that the ARUP lab tests John Chia uses are capable of detecting and measuring individual titer levels for each of the 6 Coxsackie B virus serotypes, whereas in the 1991 paper, their IgG test just measured the...

Here is something that those skeptical of the enterovirus theory might like: I just came across this 1991 paper, which found that there was no difference in IgM and IgG antibody titers for coxsackievirus B in ME/CFS patients and controls. This is in contradiction with Chia's results, which...

Preachy is not really my style, so sorry if my comments read like that. It's not the disagreement that concerns me, it's the fact that those disagreeing are not really explaining why they disagree. I like discussions based on facts, evidence and theoretical considerations, rather than based on...

I believe it was the CDC which analyzed some of Dr Chia's stomach tissue biopsy samples, and could not find enterovirus. I know that when the CDC received Chia's samples, instead of getting on with the job of testing them, they left them on the shelf for a year before they got around to...

No, this time we seem to have made progress: I've shown in the post above that several of the things you believed about enterovirus research were not correct. And you now seem to have shifted your position from "no convincing signs of infection" to accepting enterovirus infection exists in...

Agreed, in other words, association does not automatically imply causation. But earlier you were saying that there were no convincing signs of infection, which is a different thing to saying there is an infection, but it's uncertain whether this infection is the cause of ME/CFS. But if we...

I have no desire to be critical, I just want to prompt a good discussion on the subject, that addresses specific points and details. Skeptical views are very useful, but only if they provide supporting facts and references, otherwise no dialogue can be had. Let's focus down on the specifics...

You are providing an opinion that enterovirus research does not show promise, and say that "there are many more interesting avenues that show promise", but you don't explain why; you don't provide a factual or theoretical explanation for why you believe that. That's not really conducive to any...

There were lots of studies in the 1990s that found chronic enterovirus infection in the muscle tissues of ME/CFS patients, using PCR on the muscle biopsies to detect the enterovirus RNA. Those studies are listed in this post. For example, this 1993 study of 158 ME/CFS patients found enteroviral...