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Declining trust in Zeus is a technology The latest blog from Adam Mastroianni: There are some stats suggesting there is declining trust in educational institutions, then It reminded me of listening to a doctor on the radio recently who was very concerned that people are spending a lot of...

:thumbup: all power to you @Solstice On peripheral O2 extraction So, an interesting difference in peripheral oxygen extraction (lower in Long Covid). But the sample size is even smaller than the whole (fairly small) study sample size. So, I think, essentially oxygenation was reported...

I don't think it's quite like that though. The task is in fact being achieved and there is a willingness to do it again, it's just that incredibly rapid reduction in the ability of it to be achieved again. I get that too, I'm not sure if I'd say it's necessarily a part of PEM, it depends on...

So the quantification of GABA+ is from one relatively small bit of brain. Just noting this. Abnormal results might be the result of some technical problem or some medical problem unique to the subjects, but might also be related to a transient impact of PASC. (It would be good to see this...

Sample size of 18, with their symptoms having reportedly relatively mild impacts. 20 controls

I think I'm not talking about the absolute loss of function in a stroke (that arising from the "hole" in the brain), some of which can be ameliorated by finding different ways of doing things. Instead I'm talking about how some tasks can be achieved, but not repeatedly. What is the process of...

Someone close to me has recently suffered from a stroke that has affected their language ability. This person now has to work hard to read simple words, one at a time. And he can only do that for a while before feeling exhausted. When rested, he can write a few sentences for a thank you note...

Most of these people without antibodies had compelling evidence to suggest that they had indeed had the infection. There's a bit of an issue with that last sentence, as not all of the people who had ceased working were working full-time before becoming ill. So, we wouldn't expect them to...

So, a significant loss to followup. Mostly female. I'm not sure how to explain the 1 month delay in Long Covid onset in nearly half of the participants. Does an immunological pathology take time to set in for these people? Or is it just that the person has rested during the acute phase, and...

I'm aware I'm giving weight to subjective SF-36 results and discounting measures that might be regarded as objective. I think in this case it's ok. As I've said, I don't think the walk test and step test are very objective. I consider myself significantly affected by my illness, but I don't...

It's been cited again in Balancing the value and risk of exercise-based therapy post-COVID-19: a narrative review, 2023, Singh, Chalder et al.

I'm sure that that sounds very reasonable to most people. But we know the quality of a lot of the "evidence" that is cited in support of the idea that exercise training programmes are useful. Here's one I hadn't seen before, but the forum did already have a thread on it: [7] Lau HM, Ng GY...

The cardiovascular performance was measured by largely subjective measures. Although some measures of musculoskeletal performance improved more in the supervised exercise group, some weren't, even after intensive training. Given that the treatments were unblinded and there was a lot of...

RESULTS Mean change 6-minute walk distance (m) Controls 614.3 + 20.7 = 635 ___ Exercise 590.7 + 77.4 = 668 Mean change Predicted VO2max (ml/kg/min) Controls 37.8 + 1.0 = 38.8 ___ Exercise 35.1 + 3.6 = 38.7 VO2 max was not actually measured, but was estimated based on a walk test and a step...

I also note that the training programme was 6 weeks long, with evaluation at the end. That is not long enough to identify any sustainable benefit. Those people with a post-viral fatigue syndrome/ME/CFS may be swapping out some of their tasks of daily living for the prescribed exercise...

I agree NP IACFSME could shut down their journal and save money. People with useful articles about ME/CFS and related topics have many better options. Editorial decisions, such as publishing one of E. Crawley's papers, have caused more harm than good. While Fred Friedberg is President, I...

I suppose the only bright side to this is that the cohort was employees from one hospital. And surely some of the participants will understand that it's highly unlikely that it was the wonders of 30 minutes spent with Christiane Waller that was responsible for any real improvement over time...

Oh dear. Nice commentary SNT.