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From the introduction — PCNA is Proliferating cell nuclear antigen (Wikipedia) PAF is aka PCNA Clamp Associated Factor (GeneCards)

In News from US —

FDA appoints Tracy Hoeg as acting director of drug evaluation center (Reuters) Lead author of How methodological pitfalls have created widespread misunderstanding about long COVID (2023)

There is something to follow: do no harm and don't make things worse. If a guideline helped a doctor recognise that there's a serious condition centred around PEM and that advising exercising and pushing through is the very worst thing to do, as Trish says that would be an advance. I just...

Or an absence of those effective interventions you thought existed. Also research… research might just possibly help a bit more than rehabilitation. Adequate financial benefits would indeed by nice in the meantime.

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender Excessive exercise impairs cognitive function, but the underlying mechanism remains unclear. Here, we show that excessive vigorous exercise-induced lactate accumulation stimulates muscles to...

Identification of Novel Reproducible Combinatorial Genetic Risk Factors for Myalgic Encephalomyelitis in the DecodeME Patient Cohort and Commonalities with Long COVID BACKGROUND Myalgic encephalomyelitis (also known as ME/CFS or simply ME) has severely impacted the lives of tens of millions of...

A post with a few replies from people who continued to exercise and experienced a slow decline in function until it all just stopped. Basically — ME/CFS patients: I was very fit and I continued exercising until I crashed out to bedbound. Doctors: Yes, you're deconditioned. Have you tried...

Yes, the fovea is for sharp, central vision, where retinal capillaries would be in the way. See Wikipedia.

Yes if "the eyes are the windows to the soul" then the retina are windows to the vasculature. Here's what the discussion said —

Robust antibody and T cell responses tracked longitudinally in patients with long COVID After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a minority of patients experience persistent or emerging symptoms, termed ‘long coronavirus disease (COVID) or post-acute...

It depends what you mean by major structural. It's not large lesions like infarcts or widespread demyelination or inflammatory changes. But it may still be "major" but happening in a generalised fashion at a microstructural level, particularly affecting white matter or causing blood-brain...

Yes the relevant pull quotes at the end of their discussion are — i.e. #AllTestsAreNormal ain't.

Now published — Integrative multi-omics framework for causal gene discovery in long COVID Long COVID, or Post-Acute Sequelae of SARS-CoV-2 infection (PASC), affects an estimated 10–20% of patients and presents persistent multisystemic symptoms. Although demographic and clinical factors, such...

Another blog post by Fred Rossi, following on from Why I Can’t Just Meet You for Dinner: The Reality of Post-Exertional Malaise https://substack.com/home/post/p-180446599

This one's probably not too relevant or useful, as it's looking at recovered patients rather than LC, versus healthies. Mixed hospitalised and non-hospitalised acute Covid. Majority male.

Good man. I see he has varied medical interests, but in 2001 he did an otology fellowship at Green Lane Hospital in Auckland. (Back when it was still a renowned hospital doing heart and lung transplants etc, before becoming an outpatient clinical centre. There were a few interestingly named...

Excess mortality at ages 20–64 from 2020 to 2024: a comparative analysis of 16 European countries INTRODUCTION Emerging evidence suggests that young and middle-aged adults may experience postacute sequelae of COVID-19, increasing their risk of cardiovascular complications. However, it remains...

Brain MRI findings in patients with post COVID-19 condition: frequency and longitudinal changes in a nationwide cohort study BACKGROUND Prolonged neurological symptoms following COVID-19 are common, yet few longitudinal studies describe brain MRI findings in this patient group. The use of...