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Featured prominently on Hacker News today. Including this comment referencing the famous salmon paper — Which got some replies from "prefrontal" —

The more useful aspects of this study will be the proteomics, eg TGF-beta, cell motility, extracellular vesicles and platelet activation. The drug therapies probably won't shed too much light. As above, colchicine wasn't going to be useful (I think I recall them saying they chose it before...

Well the authors may not be scrambling, but their paper states — The reality might be that the reduced BOLD signal indicates increased metabolic activity. This paper said — At the least this paper renders Walitt et al.'s temporoparietal junction data uninterpretable and the effort...

I've posted a brief summary in the neurovascular coupling thread.

See BOLD signal changes can oppose oxygen metabolism across the human cortex (2025) — CMRO2 is cerebral metabolism of oxygen CBF is cerebral blood flow CBV is cerebral blood volume OED is oxygen extraction fraction GM is grey matter The canonical haemodynamic response is as above: that...

Yep, this paper will be important and of particular relevance to us, esp. via the NIH study and Walitt et al.'s claim of effort preference, with the right TPJ finding when testing grip strength. See eg thread Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional...

Published as — Mapping the complexity of ME/CFS: Evidence for abnormal energy metabolism, altered immune profile, and vascular dysfunction Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disorder with undefined mechanisms, no diagnostic tools and treatments. To...

Marcus Olang' writes I'm Kenyan. I Don't Write Like ChatGPT. ChatGPT Writes Like Me.

[31] is Cytokine Inhibition in Patients With Chronic Fatigue Syndrome (2017, Annals of Internal Medicine) | Sci-Hub

Long-term immune and epigenetic dysregulation following COVID-19 Post-Acute COVID-19 syndrome (PACS) is heterogeneous in phenotype and functional state. This prospective, observational study studied adults six months after acute COVID-19. We defined clinical phenotypes and profiled plasma...

Note this sequence — Remember that this "mystery illness" that was "an unknown disorder" was — after 4 months — clearly FND. Which as we all remember is said to be the most common neurological disorder seen in neurology practice, with clearcut rule-in signs.

OK, some summary quotes. Let me know if any of this sounds… familiar.

Letter to the Editor: Erythritol and endothelial function: interpreting in vitro findings with caution

And "a health professional" could be anything.

https://achronicvoice.com/liams-fnd-story-how-he-achieved-his-dreams/ Here's the story of a young man who suddenly developed "severe FND" at age 13. Without wishing to diagnose someone via an article, I'll simply say that from the description he gives I have doubts about the diagnosis and even...

FND Portal wrote on Bsky a month ago —

FYI @DrAnnaNZ as the immunologist being (mis)quoted.