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Now open access. Referenced as [73] in Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/CFS following exertion (2025) —

I just watched Caroline Kingdon's talk at 2h 34m (linked as the audio picks back up after the first 3 min). A very good description of her insights, working with severe patients in a research capacity. Thank you Caroline. Rob Wüst enquires at the end about the feasibility of muscle biopsy (vs...

I think that might warrant its own thread!

Eric Topol agrees.

Leveraging Explainable Automated Machine Learning AutoML and Metabolomics for Robust Diagnosis and Pathophysiological Insights in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS BACKGROUND/OBJECTIVES Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating...

From a commentary piece EBV and the making of lupus (2025) —

Reelin Increases the Sphingomyelin Content of the Plasma Membrane and Affects the Surface Expression of GPI-Anchored Proteins in Hippocampal Neurons Sphingomyelin (SM) is primarily located in the outer leaflet of the plasma membrane. It plays a crucial role in intercellular communication and...

Healthcare Situation of 3,345 Long COVID Patients in Germany: Results of a Nationwide Survey Article in German BACKGROUND Long COVID includes persistent symptoms after SARS CoV 2 infection and leads to multiple physical and psychosocial burdens. METHODS Between March and April 2025, a...

This is the passage at 8:09

Alzheimer Disease Patients Who Survived COVID-19 Have Rapid Disease Progression and a Higher Risk of Death at 5-year Follow-up: A Retrospective Cohort Study PURPOSE Alzheimer disease (AD) is the most common neurodegenerative disorder, affecting millions worldwide. COVID-19 has increased the...

Yep I have the same Pavlovian response (trauma-informed haha). This is a UCL / Barts / Southampton / Exeter team, including Melissa Heightman. The following passage was included — Prof. Murray was quoted in an article in 2021, noted in this post —

Development and implementation of a digital health intervention in routine care for long COVID patients: a comprehensive synopsis BACKGROUND By July 2020, large numbers of post-COVID patients were experiencing symptoms for weeks or months, but traditional National Health Service models of...

Pursuing Reduction in Fatigue After COVID-19 via Exercise and Rehabilitation PREFACER: a protocol for a randomised feasibility trial INTRODUCTION Over 777 million COVID-19 infections have occurred globally, with data suggesting that 10%–20% of those infected develop Long COVID. Fatigue is one...

Now published as — Resistance Exercise Therapy After COVID-19 Infection: A Randomized Clinical Trial IMPORTANCE Long COVID presents an unmet therapeutic need. OBJECTIVE To determine the effects of a resistance exercise intervention on exercise capacity, health status, and safety among...

Minute Ventilation = Tidal Volume x Respiratory Rate So you can breathe shallow but rapidly, or deep but slowly and still be hyperventilating. From Wikipedia —

The definition of hyperventilation is physiologically correct. It's not the colloquial breathing too fast. Ventilation is affected by respiratory rate and tidal volume (+ airway resistance, diffusing capacity etc), and hyperventilation is "over-breathing" in comparison to the actual metabolic...

So much for MS with functional overlay / comorbid FND. The symptoms and disability are driven by pathology in the normal appearing white matter. Functional neurological disorder in multiple sclerosis: A prospective study (2025) The borderland of multiple sclerosis and functional neurological...

Normal appearing white matter and disability in multiple sclerosis BACKGROUND AND OBJECTIVES Multiple sclerosis (MS) is characterized by lesions and atrophy on conventional MRI, yet these often fail to explain disability. Diffusion MRI (dMRI) detects microstructural injury with diffusion...