If there is actually atrial going on it would be useful to know. But if this is just open label treatments then there is the usual problem of...
I wan't actually asking about effort. I was interested in what you meant by exertion to try and understand what you see as a problem
What do you mean by exertion, @duncan? Most people do pretty much equate it to effortful action. If you mean usage of respiratory metabolic...
If the idea is that this is a disordered signalling loop then yes that certainly makes sense. You might nudge the loop back into an upward spiral....
The simple problem is that we have no reliable evidence of there being benefit. I don't discount the conceivability that there is some ongoing...
Sadly I do not think this is realistic. I am beginning to understand that looking after VS ME/CFS requires a very high level of skill even to do...
Yes, 'sickness behaviour' is a dreadful term, based on what animals do when you inject them with nasty stuff. Presumably they feel awful but you...
Perhaps another point is that this discussion arose in the context of very severe patients not being able to feed. I think it may be very...
We don't actually know that saline helps through volume expansion. The amounts given are unlikely to make much difference even short term. There...
The athlete example works for these but one key point is that the time course in ME/CFS makes no sense in these terms through any mechanism that...
There are lots of examples where disease symptoms are not signalling effects. If you are diabetic and your leg goes black with ischaemia going to...
I need to emphasise the point that there are several parallel components to the process, but one of them I think is exactly this. As I get old,...
Yes, and that would fit with a signalling error along the lines of something like 'sickness behaviour' without necessary needing inflammation as such.
But in a way this is the exact opposite of my position. I would like a scientific explanation in the long run but when considering treatment I am...
Greenhalgh seems to have lost the plot completely. If people have prolonged symptoms from organ damage that is just what we have seen with organ...
It might be, but then it might be something of the same sort but importantly different. When I had Covid I had 'sickness behaviour' as for flu. I...
One point I just realised is that if someone is sitting up almost by definition they are at risk from aspiration because any gastric contents...
I am not sure there is anything very robust. But impaired oxygen extraction would suggest to me that the cells had received signals that inhibited...
I don't really follow. I am suggesting that ATP is not being used because its use is blocked or not switched on probably via the balance of...
There are lots of theories but I don't see those as ME. I see ME/CFS as a clinical pattern of illness that we want to find the right theory for. I...
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