Something like heat shock proteins being dysregulated might explain the poor stress and exertion tolerance of patients (they don't just protect...
Not liking the positive spin in the abstract. The questionnaire results don't look impressive and are uninterpretable due to lack of controls. I...
Illness doesn't begin at diagnosis. It's likely that all these people are already sick with whatever illness they have, even if it takes another...
HSF2 is required to maintain cell-cell adhesion HSF2 deficiency leads to downregulation of cadherin superfamily genes Impaired cell-cell adhesion...
Blog by a person who tracks her health data over time. [MEDIA] Observations Summary: Fluctuations in temperature, resting heart rate, inverted...
Hanson et al did not report which type of cadherin was elevated in ME/CFS, if any. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931008/ If one...
Adhesion molecules are cell surface proteins that mediate the interaction between cells, or between cells and the extracellular matrix (ECM)....
Something that has also happened to me is eating a lighter dinner than usual, and the next morning going out for a walk after the usual breakfeast...
When reading papers like this, I always have to think back to when I was getting therapy for "school refusal" (actually crippling fatigue, but...
A bit more information on what the WAVE3 gene does in the cell besides having something to do with mitochondria. It's part of a protein family...
Increased expression of this protein seems hard to interpret because it's involved in so many different things. But that the NIH is doing a...
My understanding is that the link to mitochondria is autophagy (degradation of damaged cellular components) and maybe also organization of the...
Processes this gene is involved in involved_in actin cytoskeleton organization IBA PubMed involved_in actin filament polymerization TAS PubMed...
The pre-publication thread has been merged with the thread on the paper. Link to paper's abstract here:...
I also doubt that PEM defined as pattern of symptoms worsening with a delay after exertion is unique. But it could be a situation where there are...
I had a pulse pressure of 20 at times. I interpreted it as likely being due to low blood volume (mimicking the effects of major blood loss). It...
I should mention that I can have PEM before sleeping too, but my typical presentation is next day PEM after sleep. I don't know enough about the...
It's difficult to know what really happened. It's possible to emphasize different symptoms and aspects in the same disease. That Ramsay...
I took manganese for a while after finding out I may be deficient as it seemed like potential cause for some of my symptoms. My impression is that...
This idea has come up before and I thought it would be interesting to write down some of my thoughts on this. Housekeeing processes have a role in...
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