I'm assuming your "below 15% of the RDA" means below 15% of the normal reference range for plasma vit B3. You're right there could be a limitation...
Good critical question. When I first encountered the 5 mutations in IDO2, I was looking at genes one by one, manually. I started with all the...
We are already measuring cell serotonin in our mixed population of PBMCs, but it's likely that only the dendritic cells are in the trap, so it may...
Yes, depending on which isoform of TPH (the first enzyme in the Trp-to-serotonin pathway) is expressed in serotonergic neurons. One isoform is,...
The IDO metabolic trap cannot occur in any cell type where TDO2 is is expressed. The TDO2 gene product does not undergo substrate inhibition, so...
Good question. For the moment, we are relying on the high probability that any normal control has a 40% chance of being at least heterozygous for...
If you have seen single cell RNAseq data for cell types where only IDO1 is expressed and not IDO2 or TDO, please point them out to me. One place...
In biological terms, what happens is that (after the point of no return) IDO1 is now inhibited by its own substrate, Trp. Importantly this can...
Alex, I agree with you that bistability is a natural way to think about CFS. And having grown up in non-linear systems theory in the 1960s before...
I've thought a good deal about this. Ron has too. One way is to simply consume too much Trp. The gut, the BBB and the neurons all use the same...
@Simon M Thanks for thinking about the metabolic trap so carefully. JaimeS sent me your questions, and as I read through them and some of the...
This is a nice summary. The only error is mine, not Simon's. My error was that I said there were, on average, 1.7 damaged copies out of 2. What...
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