@Trish It's true that the original group of 20 in Ron Davis' OMF-funded big data study were identified as severely ill. But we now have sequence...
Right. You probably remember that I was looking only for common variants because I felt (and still believe) that common variants are required to...
It is intrinsic, but only to nonlinear systems. Of course, as you point out, almost every interesting system is regulated, and typically that...
It's thought that IDO2 is the ancient gene and IDO1 evolved from it by duplication and divergence. They are next to one another on chromosome 8....
I think I've read all that Craig has written on catastrophe theory and ME/CFS, but I haven't seen a particular part of cell biology or physiology...
First, in case it's not already clear to anyone, I'm the author of the IDO metabolic trap hypothesis. I think most S4ME members are aware of this,...
@strategist This is why I asked Chris if the Biobank data we see online are filtered in any way. As for the IDO2 sequencing method, it is Peidong...
@wigglethemouse In your table from Biobank, there is a column labeled HWE, which I imagine is an abbreviation for Hardy-Weinberg equilibrium. Can...
Chris, Does "Variant annotation dubious" mean that the Broad investigators think the existence of the variant is dubious or do they mean that...
I used this phrase because the strategy we employed was to search for genes coding for enzymes or transporters with common damaging mutations....
@Chris Ponting I'm always going to defer to your expertise on genomics. But I am going to ask questions. First question is this. Some people tell...
Yes. I suggested all of those as reviewers. Also Travis Craddock in the Broderick group.
This question can be seen as a variant of your sudden vs. progressive onset question. Trapping more cells of a given cell type or trapping new...
An upper limit on cellular Trp? Certainly there is the limit of solubility, but below that the level achieved in any cell will depend on the...
To answer @Robert1973, your post includes many questions. I'll do my best. The IDO metabolic trap hypothesis does predict a stable steady state...
Thanks to @Michiel Tack, I now have a PDF of the Streeten (Bell) (2000) paper on erythrocyte volume in ME/CFS. Table 4 of that paper shows that...
This topic has interested me so, like Michiel, I've tracked down some of the published work. I think Michiel is correct that David Bell often...
As Chris points out there are many SNVs in IDO2. The IDO metabolic trap hypothesis, however, is not based on a GWAS approach to the data. The...
This is an interesting and important question. I'll look into it. I will, however, be greatly surprised if all our CFS patients (now n=66)...
There is a video of a talk by Michael Maes on the Australian ME group's (eMErge) site. Early on in the talk, he quotes two European government...
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