Yes, it is only relevant to malignant cells that lose CD38 by mutating and thereby become 'invisible'.
I think there may be a problem with using skin biopsies for diagnosing SFN. As I understand it the number of small nerve fibres is counted....
That is probably about all we have. If there is no sign of something like an adrenaline secreting tumour or a dangerous heart rhythm then waiting...
I think the problem is that for the tests we have it is not clear what to make of the answers and nobody knows what other tests to think up. An...
Yes, but that could mean any number of things. It is also not clear whether it means that the fault is in the autonomic system itself or something...
I agree with @Hutan that this is a potentially valid way of doing a study. But there is a potential problem that they will not know whether the...
Something that I don't actually know, despite having been a co-author of a Cochrane Review, is whether or not Cochrane Reviews actually cost...
As a physician I am not at all sure what 'dysautonomia' is supposed to mean. I mostly hear the word being used by colleagues whose scientific...
I am not sure I understand what was being looked for here and why. CSF might give an indication of what brain might have been doing but the...
Well, as Hutan points out there is huge scope for harm - and since the amount of harm is unknown it is completely unethical to behave that way in...
Spot on.
Another Guardian piece, this time on shortage of physiotherapists for children. Maybe some are badly needed but maybe someone needs to check...
Sorry David, I posted a tidied up version of the letter without the title by pasting from Word. The title is “Advocates of the intervention...
So when does hardware become firmware or software? Looking back at the old BBC-B computers with software chips it is all rather unclear. Neural...
Is there any evidence for amalgams causing a problem?
I don't think BMJ will run it because I mention a name - Chalmers - and that is not allowed. So by all means post it. The version sent was: Dear...
And that is an anecdote @dave30th ;). Remember when Michael Buchanan came back to us and said that an eminent Cambridge statistician thought PACE...
OK, so we probably agree roughly on that. But why is it 'software', since it is going to be neuronal microstructure presumably that mediates...
Yes, that is why we test drugs on rats and if they work on rats we test them on humans. But the analogies need to be realistic. The sets and...
It looks like it has gravitated to 'activity management' = GET. I am sorry that I was not of more use here.
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