Nobody said ME isn't post-viral. Viral onset may be the most common onset, but it is not the only one. There are several onset triggers and too...
Overtraining Syndrome - PMC (nih.gov) In particular, look at Table 2 from the ECSS definition. I can't find the original ECSS paper, but I'll post...
GWI sleuth work has lead to a partiular chemical weapons disposal site, I've heard. IH/CCI cases also do exist and can't be ignored, though those...
Only to people obsessed with validation of their disorder. There have been hundreds, if not thousands, of papers on physiology, more than those on...
Right, a quick look at something let's you come to a quick conclusion. That, btw, sounds awfully similar to what people used to say about MECFS....
Hmmm, Jonathan says nothing, while Monje says something. I'll have to think about this, man.
No idea on specific physiology, so I'll have to defer to researchers and experts. But Monje's study did show glial activation in hippocampus,...
One theory I'm aware of: proinflammatory cytokines -> BBB breach ->monocyte recruitment by glial cells? Or something like that. There was a...
OTS produces a set of symptoms identical to MECFS in both men and women. Along with disorders like concussion fatigue, GWI, and some cases of...
It actually goes both ways for MECFS. Some people with sudden onset just assume that it is an infection without diagnosis. Bruce Campell and his...
No it doesn't. I just threw it in there. :) That has been the common question whenever overtraining is mentioned as a cause. One of the...
Is it fair to say inflammatory cytokines are inflammatory agents? The thesis, afaik, is that the inflammatory agents cause breaching BBB causing...
Depression as part of sickness behavior, yes. FADE is not. One can debate FADE is real or not, but overtraining syndrome is real. And OTS appears...
Next to viral infection, overtraining appears to be. Julie (Meyer or something), an Olympic rower. Dean Anderson, competitive cross-country skier....
Paroxetine for the Prevention of Depression Induced by High-Dose Interferon Alfa | NEJM, metioned in Inflammation of the body may explain...
I would think inflammation's roll in depression and weakness is now well understood and accepted. And the emotional change accompanying PEM is...
Allow me to add chronic inflammation from stress to the pathogenesis. Overtraining, in particular, has been one of the more common causes MECFS....
Ha, this was exactly what I was saying a while ago when they came up with the study showing vascular damage in long-COVID: whatever was causing...
This is what I've been think about too. I've heard that microglia has multiple states, not just on and off. Perhaps there is a state that it gets...
That would be impossible to know for something as complicated as MECFS. I was speaking only in theory. Personally, I'm not trying to model the...
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