I agree, if something is quickly eased by rest within a few minutes then that is not PEM. It doesn't meet the prolonged criterion. For me,...
Really good question. I experience both immediate and delayed PEM. I had a visit yesterday - I only manage a few a year - where I talked to...
I looked at Moore et al. 2023 again - this is the study from Hanson's group called "Recovery from Exercise in Persons with Myalgic...
The Institute of Medicine report in 2015 (now National Academy) does not emphasise delay they way the CMO report (UK, 2002) did. Here’s how they...
The MEA and the International Consensus Primer and buckets of other sources have always talked about "immediate PEM" and "delayed PEM". Are those...
Regarding immediate PEM, I think Stussman et al. 2023 is interesting. That's the substudy of the NIH study that looked at PEM following CPET....
From that info alone, I don't think you could definitively say, that is or isn't PEM. But you could say, that's not normal. If I read about...
I think defining PEM only as a delayed crash is problematic. This is particularly important when PEM is rightly regarded as the core feature of...
They explain why here: Seems reasonable. Then they acknowledge that: I tend to think the bigger problem is the one @Yann04 brought up above:...
Or step on another deterioration landmine. I did not spend 10 years pushing through PEM, but I did spend 10 years deteriorating.
Fluge et al.'s placebo group went from 32.5 to 38.4 on the SF36 physical function subscale in 3 months. The PACE trial's specialist medical care...
Thought it would be helpful to have a record here of the detail of those studies. I put line breaks in to make these quotes a bit easier to read:...
Yes, I'm with you on that notion of "underlying ME". And yes, there are triggers other than exertion for those changes to the underlying...
The 2021 NICE guidelines say this: And I think there's wisdom in advising that anything lasting more than a few days requires adjustment of what...
Yeah, it's tricky, because I'm trying to start from their terminology, to come up with something that would have a hope of being accepted. I...
Yes but what on earth would it say?! I don't think we have a clue because no-one has followed us properly over time. There are a few studies...
Yeah, so there are two relevant bits there: If we stick with their terms (since anything else is swimming upstream), I think this would be...
I agree. Things that were mystifying when I was mild are very clear now that I'm severe!
Gotcha. For me, "permanent deteriorater" conjures up someone who is constantly getting worse, rather than someone who got worse after a trigger...
OK, I understand, so what you mean is a deterioration with a clear trigger. Many of my steps down during the 10 years of deterioration had a...
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