@Hutan - speaking for myself, MUPS is a clinical thing only in the minds of those who promote it. IMO, it's unscientific to base a clinical entity...
Sorry for not being clearer. My understanding is that based on studies showing reproducibility with other diseases, she had expected to see it...
Yes, but the very first time she tested an ME patient, she was expecting to see reproducibility because that's how it is in other conditions. The...
I understand from discussions with people at Workwell that the test has been shown to be reproducible in various diseases by repeat testing. This...
My understanding is that repeat CPET tests are reproducible (have low variablility) in healthy people, in a number of chronic conditions...
I participated in a 2 day CPET study with this group as a sedentary control and assume that study is reported in this paper. As noted in the...
This 2017 paper by Murdock et al evaluated the MFI-20 in ME and reported ceiling effects, and problems with validity and reliability. From the...
Good question and probably my fault as my question above took it outside the scope of this thread so some of the following responses belong in...
Assuming you mean reason for not giving a date, no they did not. As I said above, I don't speak for Cochrane but I would hope it would be soon....
@Adam pwme I've heard back from Cochrane on whether/when they will be providing an update on the evidence review. They do plan on doing that but...
I don't know why Jason used this definition of severity. And I agree with the comments above - severity can have a spectrum but that spectrum is...
@Adam pwme - Thank you for the message. And yes, I did
@Adam pwme - Thank you. This is especially helpful. Do you know of any existing instrument that comes close to assessing PEM in this way? I'm...
Interesting. To help me understand, can you explain the way in which NICE 2021 describes PEM more narrowly than Jason? And do you see any...
Fukuda is a polythetic criteria requiring any 4 of 8 criteria. According to Luis Nacul at a US meeting in 2014, 163 different combinations of...
To your second point above, PEM after cognitive or other stressors may be different from that after physical activity so a questionnaire that...
@Adam pwme - I have not heard yet but will follow up this week.
This is the crux of the issue. Studying those who meet Fukuda but do not have PEM may be important. But today, researchers are still using Fukuda...
My point was purely about the criteria, not the quality of the methodology or findings . Even if the study is superbly designed and executed on...
This post has been copied and following discussion moved from this thread: UK NICE 2021 ME/CFS Guideline, published 29th October -...
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