Getting organised to submit an FOI request is very much not my skillset but trawling through 1000 pages of correspondence looking for a smoking...
Excellent diligence, Lone wolf! I respect your grind a lot.
This is an excellent question. We can cut it by significance and we should. I'll try to do it myself at some point soon but if someone else wants...
One possible thing we may be able to point out is that untargeted metabolomics delivers no consistency in findings and isn't worth pursuing. In...
I'd like to shout out to a couple of inspirational projects for this kind of meta-analysis. Brydges, Che Lipkin &Fiehn 2023 and Kaczmarek 2023....
So this is some code for analysing the Hanson 2022 data. https://github.com/jasemurphy/mecfs/blob/main/Hanson%202022.R and this is the data...
I'm keen to see if we can trawl existing data to find patterns. There are enough small and medium-sized studies out there - could real findings...
I have no idea who is right but I like that Prof Scheibenbogen et al are not playing collegiate and politely ignoring a study they disagree with....
I'm not sure they've identified people doing intermittent fasting very well, as opposed to people skipping meals. They have a 2-day eating recall...
Yep, Rob Wust found necrosis in muscle cells after exercise (pictured below, panel B). A possible explanation is acute endoplasmic reticulum...
There's also this "anticipatory" UPR pathway, which is not very well described in the literature yet but affected by estrogen, which is relevant...
When I want to feel hopeful I re-read this paper. The irony is that while Wallitt was wasting $8million on his silly preconceived notion, on the...
A detail in Hwang's 2023 WASF3 paper is that the UPR he found isn't working right. While PERK is switched on, there's no phosphorylation of eiF2a....
I'm extremely excited by the WASF3 work by Hwang et al; so I can't help wondering about a possible link from their finding of endoplasmic...
I really loved this article. I did a bunch of reading on how they developed the cure. It's worth understanding what pathways to success look...
I recently joined this forum and am posting links to some of the analysis I've done in recent years. One big piece of work relates to this Hanson...
Thanks for the kind feedback and intelligent questions. just the few mecfs studies I've looked at. I started this project expecting to find a...
A long time ago I compared the findings of this study to those of Germain, Hanson et al 2018. You can see the results below. Agreement between the...
I agree with this take. The metabolome is very dynamic and highly individualised. Which means I think that a lot of metabolomic snapshots are less...
Related to peroxisomal function and a key product of the peroxisome, the plasmalogen: Having considered this paper on plasmalogen replacement...
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