I also am helped by stimulants. I was surprised that it was so rare to be able to tolerate them.
It’s really just meant to be a space where people can ask questions about things they’ve been struggling to understand and get as simple an answer...
Thanks for the clarification, I had missed your earlier explanation that interferon I production was also dependent on ROS and misinterpreted your...
Hi @paulendat, welcome to the forum! It's great to have more people with an immunometabolism background interested in ME/CFS! I’m very interested...
My contribution to the discussion has mostly just been “there’s no need to to claim mitochondrial abnormalities or a (full stop) lack of ATP for a...
Thanks for sharing your experiences and thoughts! For what it’s worth, it think the predictable and reliable part is something that is only...
I assume the former—NAMPT was one of the top genes identified, which is involved in an NAD production pathway
Yes I did! It’s a possible upstream mechanism that could lead to the malate-aspartate shuttle abnormalities I’ve hypothesized (at least in certain...
I don’t think there would be a problem with duplication, since paper-specific explanations/summaries would still only be on the paper-specific...
I think it would be nice to have concise and accessible summaries for research papers. My only concern is that making this a site-wide feature...
That’s a great idea @Trish, thanks for the feedback. I’d be happy to help with curation, though I will likely be prone to disappearing for periods...
That caught my eye too. I guess the lockdowns were awful for humanity in every possible way, except they gave people the opportunity to perfect...
I think we're on the same page, some signals are just getting lost in transmission!
Since we have such a lovely millieu of well-informed folks with a wide variety of background knowledge, I thought it might be useful to have a...
I think they're specifically saying that their highly associated genes have a greater-than-expected-by-chance overlap with the set of genes that...
I may be misinterpreting the methods (they're a bit vague on details), but I suspect it would be because they are actually comparing p-values...
Like @Hutan I don’t think it’s definitive. But given the rarity of their variants and the small sample size, the independent cohort validation...
Side note @forestglip since you mentioned you were unfamiliar with Bayesian statistics: our thought process about the two >0.9999 p values is...
I’ll send them in the mail, please allow 7-10 business days.
Interesting that we had a similar experience. I tried to look into a biological explanation awhile ago but couldn’t find much of substance. But if...
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