I've just read the abstract so far, but if the findings are solid (and I generally trust this journal), this is a BIG finding. Unfortunately it...
macrophages come from monocytes! (if they're not self-proliferating tissue-resident macrophages)
IRG1 encodes the protein that catalyzes itaconate production--they did an IRG1 [edit: knockout] to see if interferon beta production is dependent...
To paulendat's earlier point, I've found this paper: https://www.nature.com/articles/s41598-020-80933-7 Which shows that endogenous itaconate...
As in knocking down a specific gene in a cell line or mouse to see how it functions without the protein from that gene
It's a potential PhD thesis. My work would be focused on the multi-omic integration part, since that is what I've already been working on. The...
Preferential glucose sequestration by greedy activated macrophages?
I seem to have a habit of arriving to a new topic (for me) and coming up with brilliant ideas just before reading the paper that spelled it out...
If he's speaking about the macrophage itself shutting down then I think that's where the hypothesis would need to be amended--macrophages become...
I for one am open to the idea of an adaptive immune shift, though I think metabolism is the link that could define a positive feedback loop. Given...
It's not inhibiting it's own metabolism per se, but rather shifting towards glycolysis which can be mobilized much more quickly, even if it is...
Thanks for the clarification--I'd be really interested in your verification. If it's true that it is not a potent enough SDH inhibitor, I'd be...
Those are all great points, though I wonder if that's something that would be addressed anyways through an in-depth interview. The point of...
I’m taking 400mg at a time for the malic acid so yes I think what you have would be enough to tell if it works for you. [edit: malic acid would...
Please keep pointing out problems! I may be better than your average clinician/researcher at spotting problems (it’s a low bar) by virtue of...
I appreciate the questions since it helps me flesh out this idea more :) From seeing discussions on this site I think there actually is an...
It’s likely that DecodeME results will be out before I have a chance to put this together anyways, so I definitely will. However, it’s very...
Mostly it’s a matter of finding homogenous study groups in the absence of a clear marker which defines all ME/CFS (if that exists). It makes it...
That would be great if possible, it would just be a matter of whether the data collected, on either the sample or patient reported outcome side,...
Yes I had this thought—it could be adapted for severe (though possibly not very severe) by being an interview over text or through email link with...
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