I agree with you on the logic here—my thought is that the cocktail of predispositions are what prevent the boot from doing a good enough job. As...
Yes, to clarify, I meant “predisposing conditions” which could be environmental. Though certainly one of the predispositions could be a genetic...
Bone marrow derived macrophage levels typically fluctuate in response to some insult, but there are also tissue resident macrophages (e.g. the...
The relationship between itaconate, interferon beta, and ROS/PRDX5 is what was found in the paper. A prior paper showed that natural itaconate...
If my speculation is correct, it would be because it requires a hefty cocktail of predispositions before the heavy boot becomes inadequate at its...
This gives me a couple hints as to how the malic acid works. Based on my hypothesis, you’re supplementing malate that would normally be...
I decided to carefully test the upper limits of my activity since I knew I’d have extra recovery time coming up if I needed it. I think what I...
If I’m not mistaken, I think the positive feedback loop Phair is proposing is itaconate -> interferon alpha -> itaconate. I know that interferon...
At this point, my sense is that it is both a cell metabolism and an immune signaling problem at the same time. E.g. immune stimuli cause metabolic...
@Yann04 Hutan's original summary of the talk (corrected at point #2): paulendat's correction that prompted Hutan to modify #2 above: Hutan's...
That's what I suspect, since as Hutan noted earlier, people who are treated with interferon for other infections often report very similar...
I see your point here. Though the more I personally experiment with supplements that affect metabolic function, and see their unique effects...
Hutan made a correction after paulendat's comment and it looks like everything else is correct to me
My intuition keeps pushing me to the idea that metabolic regulation in innate immune cells is precisely that "railway switch". It seems that...
My bad for misleading you @V.R.T.!
Having read the full paper now I’m a bit disappointed that they only examined PBMCs after external administration of the Lyme peptidoglycans—I had...
The idea would initially be at baseline w/o PEM—I’m fairly confident that at least some signature can be picked up outside of PEM. I’m not...
At the moment I only have speculation with a lot of unknowns. My suspicion does not rely on autoimmunity. Rather, I'm tossing around the idea of a...
Was not suggesting using it as a therapeutic! Just wondering aloud about potentially using co-IP or another method to determine if there is...
Ah thank you, I misspoke. Yes I'm familiar with the pathway from a rotation professor that was interested in CRISPR screens of homeostatic...
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