I personally don't hold much faith in "energy diversion" theories since abnormalities in ATP production in ME/CFS have been found in various cell...
They only tested SARS-CoV-2 spike so it absolutely could be something that other viruses can also do.
One way this paper could have been improved is by knocking down MAO-B in the cells and seeing if the observed bioenergetic changes still occur...
Kind of--it's less murder and more death by neglect, since it wouldn't be good for the virus if the cell dies prematurely by suicide or murder....
Agreed. All the explanations I've seen rely on just the possibility of CNS interactions with the rest of the body rather than anything concrete. I...
I'll preface this by saying that I'm by no means an expert on the topic here--my experience comes from spending time discussing similar cell bio...
There seems to only be a handful of papers thus far examining SARS-CoV-2 interactions with mitochondria at all, so brain-specific mitochondrial...
Here's a PDF of Van Oudenhove & Cuypers (reference 5) if anyone wants to read it
Having just finished reading that reference (Van Oudenhove & Cuypers, 2014), I don't think it's particularly useful as a critique of psychosomatic...
I take your point here—I think the BPS camp themselves is just dedicated to willful hermeneutical ignorance at this point. By “battling” them I...
I think it is worth battling the BPS camp on their own philosophy-of-mind terms, since it reveals the logical inconsistencies inherent in their...
A bit of clarification here, since I can’t resist jumping back into my philosophy of mind days. Supervenience is a thesis in philosophy of mind...
Interesting change I’ve noticed over time: the amount of malic acid I need for the same effect is decreasing. Perhaps it’s building up in the...
Thanks for sharing your story! Given that our study identified differences in both androgenic steroids and pregnenolone (the latter of which is...
That concern drove a lot of our choices in the analysis. Initially we started off doing a completely unsupervised multi-omics integration...
That’s a good concern to have. I think the answer is yes and no (though more "no" than "yes"). Yes, because we did not have non-hospitalized...
If I’m understanding you correctly, you’re referring to the changes over the course of hours, perhaps in response to something like exertion?...
Oh sure! It’s absolutely understandable to find it confusing since there’s a technical definition and a more colloquial meaning, and it can be...
Great question! It would all be dependent on the stoichiometry of the reaction at hand, whether baseline levels of the metabolite are even...
Hi all! I wasn't sure if the forum would have some discussion of the preprint, or if that would come later when we finally got published. @Hutan...
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