Thanks for your engagement! I actually did a similar analysis when I was trying to characterize some of our findings for the text. Unfortunately,...
So if a shift in macrophage cellular metabolism triggers the release of cytokines that cause muscle pain but don't, on their own, cause...
Yes I believe that's the one! Thank you
The explanation doesn't require histopathological inflammation at all. As you said yourself, cytokines =/= inflammation. All you'd need are the...
I agree--I've been eagerly following the systems biology work by Nicolas Chevrier showing that pairs of cytokines elicit specific transcriptomic...
Interesting to see iron come up again as differentiating hospitalized LC vs. hospitalized recovered patients. Ferritin was noted in Hanson et...
I'd be interested to hear when you have a chance. In the mean time, there's still evidence of similar cytokine responses in influenza and typhoid...
Not tactless! Yeah, she was talking about other patients who had a sports-related injury a while back and continued to have pain and...
See above message, I also personally know two people with ME/CFS that have reported similar experiences with taking NSAIDs ahead of time. (Small...
That’s interesting! In my case, I’ve been able to increase the amount of time I can be continuously active and substantially lessen PEM by taking...
@Jonathan Edwards thanks for the clarification, I will be more specific in my language to avoid confusion. As a follow up, what do you think is...
Can I ask what evidence you're looking at for lack of inflammation? I've certainly seen papers of the years showing a differential cytokine...
That’s a great question, I’ve definitely experienced it myself with PEM. I have a feeling it’s related to catecholamines...
I think that part is mediated by the immune system! Particularly macrophages, which would be shifted into a pro-inflammatory phenotype if they are...
I would expect to see a big difference in cases where Oxidative Phosphorylation is almost completely inhibited as in your examples vs. cases where...
Unable to link specific studies now as I don’t have my laptop today and am on my phone, but you’re right that it’s inconsistent across studies....
I did a bit of single-cell RNA-seq and TCR-seq in a very small LC study--on a single-cell level, the VH gene RNA levels did correlate to the TCR...
FGF21 has popped up repeatedly, including in a recent LC study I did trying to predict post-hospitalization physical function. My guess is that it...
You'd have to run it through an alignment algorithm. It looks like they used IgBlast, which I haven't used. They likely have a table of sequenced...
Also, I think it's possible to have an initial systemic shift in energy production caused by a virus (or the subsequent immune response) that...
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