I should note, the timeline for PEM changed for me when I started taking a stimulant. Pre-stimulant, the pain was less sharp and tended to occur...
I’ve shared bits of this elsewhere, but my stubbornness on the role of redox balance (rather than specific mitochondrial damage) comes from my...
That’s interesting, thanks for sharing! I’m also basing some of this off of personal experience with supplements that would directly affect...
I would consider myself pretty mild over the last few years. Was able to work or attend school part time with remote accommodations for ~4 hours a...
that’s a good point! In the case of sphingolipids, I believe every cell does have the machinery to generate them since sphingolipid rafts are...
There’s also a platform called Eureka that tries to bring together people’s reports for things that worked for them for various illnesses. I was...
https://www.s4me.info/threads/malic-acid-supplement-sumac.42716/page-4#post-594525 for what it’s worth, I did also discover a huge boost from a...
Sphingolipid metabolism has popped up a few times (including in some unpublished analysis that I've done on a long Covid cohort). Iirc it was...
Exact same here! I've been saying this to my GP for years. Any time change really messes me up. Even having to wake up a half hour earlier than...
Yes, sorry. Full regimen currently is: Morning (around 8 AM): 40 mg vyvanse ~400 mg malic acid (half of 800 mg capsule) 3-4x 100 mg coq10 (a...
Another interesting thing I noticed: I’ve started to get some slight cravings for each of the supplements at certain points during the day,...
Still feeling a huge difference from the malic acid! Going on 2 months now. Even had moments where I started to feel muscle pain setting in...
Exactly the same as others here, my brain fires up. Suddenly I’m reliving conversations and jumping to memories from childhood and then thinking...
I’m late to the party here but I definitely share a lot of this and I’ve been thinking more about my “wired-tired” experience of PEM. I do feel...
I was prescribed 200 and 400 mg of modafinil a while back, it did help me increase my daily activity and gave me enough energy for part-time...
My drive-by assessment is that it is overall a very vague theory. Perhaps a few points might be plausible, but as a unifying theory of ME/CFS, it...
Fascinating, thanks for posting @hotblack!
My mother and grandmother also have hasimoto's, though I'm the only one that ended up with ME/CFS. My mother caught COVID recently but never...
@PrairieLights Would you mind sharing if your ME/CFS symptoms started due to a viral infection or not? Feel free to ignore if you do not feel...
I can share my personal experience here I've had Hashimoto's since I was a teenager, runs in the family. Was on levothyroxine only for several...
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