Unfortunately if you suggest drawing your own blood on the spot one too many times in a research setting, people tend to ask a lot of extra...
I’m only interested in them because of my experiences with “immediate” PEM primarily characterized by muscle pain and stiffness without the...
Interesting, thank you. That might be a very relevant clue. I’ll look into the literature though this might end up being a question that can only...
Follow up question @Utsikt are you getting muscle stiffness as well? That seems to be a predominant feature alongside pain and weakness in...
That would be a good thing to poll about, possibly. Though my fear is that we’re all talking about subtly different things with the same words....
Yes unfortunately that’s always the issue with in-vitro models. There are many things you can do in-vitro that you simply can’t do in animal...
That’s exactly the thread I’m trying to pull. It seems like the cytokines that are most likely to be involved in things like muscle pain and...
That’s fascinating—have you happened to see my posts about a malic acid supplement? It was a bit of a miraculous supplement for my ME. However,...
It seemed like this only happened when I was active enough during the day to “tire myself out” in the same way that healthy people describe from...
It’s funny, a while ago I started using an app that tracks sleep movement so it could wake me up at the “optimal point” within a 45 minute time...
Let me chat with a former rotation PI :) can’t make promises but it’s a possibility
Ha! I woke up with the exact same line of thought based on my earlier comment: It would make sense that more deleterious mutations in the same...
I’m aware! I don’t think malic acid would “activate” MAS, just potentially compensate for a lack of reducing agents getting into the mitochondrion...
That’s fascinating, considering some other parts of my experience. Malic acid alone gave me great physical energy at the expense of worse brain...
It seems like the only books that matter are the ones from the insurance company
Any chance those results are published or soon-to-be published? I'd be extremely interested to look at them. I'm sure other members on this forum...
No problem! HiF-1 is hypoxia inducible factor (a nobel prize winning discovery where one of the winners has quite the history of fraud, if you're...
It depends on where exactly the malate-aspartate shuttle is being inhibited (if it is at all). If it's being inhibited upstream at succinate...
Explain like I'm brain-foggy: Background: Glycolysis is the first step in cellular metabolism. It can produce some ATP on its own, but most cells...
Some interesting tidbits on temporal dynamics:
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