Have those placebo effects lasted long term, though? I've only heard of cases where there was a short term improvement but then it lapsed soon...
Interesting that you note wine--my first ME/CFS publication was actually about alcohol intolerance. Alcohol intolerance could actually be...
That’s exactly what I was thinking! I don’t think it’s a full stop lack of ATP—that’s most likely to just kill neurons. But there definitely...
I agree, I think it's an oversimplification. You said it very well
I think it's best explained by what @EndME noted earlier: even healthy people will face fatigue doing cognitive tasks. The changes are small to...
https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2014.00552/full Here's an interesting study I discussed in class that might...
small does not mean irrelevant especially in the brain.
That's a great question--and I think it's precisely the million dollar question. Unfortunately we're barely able to answer that in diseases where...
It relies on the false assumption that global ATP usage across the organ provides any valuable correlate to metabolism on the cellular level. It's...
Please don’t take that as fact—there is very little consensus in the field about that claim. There is not even consensus on how much ATP is used...
Thanks for starting this thread, I think it’s very useful to hash out. I’ve only been able to explain to friends and family by reframing what...
This was really great information, thanks for sharing! It’s really encouraging to see others share experiences that are very close to mine and...
This is why I don’t think it’s a problem for the redox theory that the brain is metabolically active all the time with small fluctuations. In...
I’ve experienced that as well! To clarify, I don’t think exertion is limited to the muscle. My NAD/NADH ratio theory definitely would not be...
Thanks for sharing your experience and thoughts! I suspect that the dynamics end up looking different for more severe folks. in the instance...
I’ve never argued that there’s no knock on effect. Quite the opposite. Please see previous messages. the reason for looking at NAD/NADH ratios is...
Thanks for your thoughts on this! I think it’s a really good perspective. I was surprised as anyone that sumac actually had an effect on me in...
So as of now if I’m counting correctly including my PMs and this thread, we have: 4 people including me who report a definite boost 1 which didn’t...
Thanks for letting me now! Sorry it did not work for you.
The heartburn doesn’t always happen, only at higher dosages than what I usually take. And when I have experienced it, it’s after other positive...
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