I eventually became a professional immunologist having been a rheumatologist, macrophage and stromal cell biologist, histopathologist,...
It depends on what signals are being produced. IL3 is not primarily an inflammatory signal: Interleukin-3 (IL-3) is a cytokine that plays a...
That would make sense to me. I think we need to see more ELISpot/FluoroSpot-type studies to pick up local cell interaction, where I suspect...
Hi Robert @RDP , thanks for re-joining the discussion. I think this sort of dialogue could be very productive. I don't think anyone has quite got...
The biggest worry I have is that anyone feeling dodgy for any reason in the months after Covid gets called Long Covid. So they may just be...
I wish people would tell us what they found rather than what they thought they ought to be looking for.
I am not sure the whole cerebellum would be squashed rather than the tonsils and they would need to be abnormal already to go through the foramen...
I have always assumed they are all bone marrow replaced. That is what I saw in the geometry of the tissue in hundreds of samples just using...
The answer you will find, in ... 'The Windmills of your mind'.
We did a lot of work on macrophage subsets in the 1990s, some of which seems to have got forgotten by recent reviews. It looked very much as if in...
Yup, that would be a going concern. I still have my prejudices but sooner or later we are going to find that one of these things can be...
This I think is the basis of the ?Dutch guy's idea of focusing on learnt innate immunity. It is conceivable that an epigenetic change occurs in...
I can't have all of you writing our new paper for us. Yes. And yes.
One of those little old positive feedback loops ;).
Yes, I am still not sure why you need any boots for this but a cocktail of predispositions sounds like the ticket (roll on DecodeME). But I think...
Yes, they learn to produce entirely new molecules in the form of antibody or T cell receptor. It is a rather brutal form of learning the kid B and...
I think that is difficult to argue. There are maybe 10,000 people with severe ME/CFS in the UK. At least a proportion of them get to be seen by...
It is odd but almost certainly what is happening in rheumatoid, lupus, scleroderma, Wegener's... most of the autoimmune diseases I came across....
My previous work makes me think otherwise though. Positive feedback loops are everywhere in the immune response. Our rheumatoid model made use of...
I am happy that the switch point is in a metabolic pathway that mediates signalling. My thought is that the positive feedback loop options that...
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