UK: Conference: MitOX 2025 - 3rd April 2025 - focus on mitochondria research

From the MitOX organising committee,

"Dear All,

We are delighted to announce that registration for MitOX 2025 is now open. Please sign up here: MitOX 2025 | University of Oxford

The meeting will take place on the 3rd of April at the John Radcliffe Hospital with options for in-person and online delegates.

For further information re MitOX, please see our webpage MitOX 2025 - 3rd April — Nuffield Department of Women's & Reproductive Health

Current speakers include:

• James Sleigh (UCL) “In vivo imaging of axonal mitochondrion transport and morphology in genetic peripheral neuropathy."
• Brent Ryan (Oxford) 'Novel methods to understand the role of mitochondrial dysfunction in neurodegeneration'
• Sheeza Mughal (IBEC, Barcelona) “Developing artificial 3-D skeletal muscle tissues to investigate altered metabolic and functional dynamics in ME/CFS and Long COVID-19”
• Jan Renwinkel (Oxford) “ Induction of innate immunity by mitochondrial RNA”
• Dr Gautam Wali (Melbourne) “Single-Cell Image Analysis Uncovers Mitochondrial and Lysosomal Defects in Parkinson’s Disease”
• Mara Artibani (Oxford) “Targeting the metabolic vulnerabilities of chemotherapy-resistant ovarian cancer”
• Luis Tabara Rodriguez (Cambridge) “Mitochondrial fusion selectivity controls mitochondrial recycling to maintain mtDNA levels”
• Enrique Rodriguez (UCL) “Anaesthetics disrupt complex I-linked respiration and reverse the ATP synthase: insights into the mechanism of consciousness”

The deadline for abstract submission is the 13th of March and registration the 20th of March. Abstracts should be submitted for short talks and posters."

Note: Online attendance is free.

 

Last chance to sign up, registrations closes at 23:59 tonight: MitOX 2025 | University of Oxford!


MitOX 2025 April 3rd

9.25 Karl Morten (Oxford) Welcome

Session 1. Mitochondrial Biology

9.30 Luis Tabara Rodriguez (University of Cambridge): Mitochondrial fusion selectivity controls mitochondrial recycling to maintain mtDNA levels

9.55 Gautam Wali (University of Melbourne): Single-Cell Image Analysis Uncovers Mitochondrial and Lysosomal Defects in Parkinson’s Diseas

10.20 Robbie Baldock (University of Portsmouth) Investigating the mechanisms of mitochondrial DNA mutagenesis and repair: ST1

10.35 Jan Willem Taanman (UCL): Inhibition of mitochondrial protein synthesis induces biosynthesis of oxidative phosphorylation Complex V and reverses its activity: ST2

10.50 Coffee

Session 2. Novel Approaches to Investigate mitochondrial Dysfunction

11.20 Ryan Carter (University of Oxford): Integrative Radiogenomics with 18F-Fluciclovine PET Highlights Reprogramming of Pyrimidine Metabolism in Primary Breast Cancer

11.45 Ladislav Valkovic (University of Oxford): Using Magnetic Resonance Spectroscopy to non-invasively detect mitochondrial dysfunction in Long Covid and ME/CFS

12.10 Sheeza Mughal (IBEC, Barcelona). Developing artificial 3-D skeletal muscle tissues to investigate altered metabolic and functional dynamics in ME/CFS and Long COVID-19.

12.35 James Sleigh (UCL): In vivo imaging of axonal mitochondrion transport and morphology in genetic peripheral neuropathy.

13.00 Lunch & Poster session

Session 3. Mitochondrial Therapies

14.15 Pollard Lecture Jan Renwinkel (University of Oxford): Induction of innate immunity by mitochondrial RNA.

14.40 Millie Fullerton (University of Newcastle): Mitochondrial dysfunction in a model of dilated cardiomyopathy is rescued by vitamin supplementation

15.05 Mara Artibani (University of Oxford): Targeting the metabolic vulnerabilities of chemotherapy-resistant ovarian cancer

15.30 Ana Victoria Lechuga-Vieco (IRB Barcelona): Metabolic Remodeling Through Mitochondrial Transfer: A Key to Enhanced Immune Responses: ST3

15.45 Tea

Session 4. Mitochondria in Physiology and Disease

16.15 Enrique Rodriguez (UCL): Anaesthetics disrupt complex I-linked respiration and reverse the ATP synthase: insights into the mechanism of consciousness

16.40 Brent Ryan (University of Oxford): Novel methods to understand the role of mitochondrial dysfunction in neurodegeneration.

17.05 Hanmin Lee (City St George’s, University of London): Characterising MRPL44(L156R) Transgenic Mouse Model: Insights into Mitochondrial Disorder Pathogenesis and Sex-Dependent Responses.ST4

17.20 Micol Falabella (UCL): Biallelic PTPMT1 variants disrupt cardiolipin metabolism and lead to a neurodevelopmental syndrome. ST5

 

I've missed the chance to sign up to this, is there any info about whether the talks will be put up online? Very interested in the artificial 3D muscle talk.

 

I don't think that these talks are put up online afterwards. However, Karl Morten has kindly shared the Teams Meeting link with me with the intention of sharing it here

Spoiler: Click for meeting link

Join the meeting now

Meeting ID: 372 292 712 572

Passcode: m4TK9eW9

This obviously will only be live just before the start time.

 

thank you, appreciate it

 

Has anybody watched the two sessions and can maybe share interesting insights?

11.45 Ladislav Valkovic (University of Oxford): Using Magnetic Resonance Spectroscopy to non-invasively detect mitochondrial dysfunction in Long Covid and ME/CFS

12.10 Sheeza Mughal (IBEC, Barcelona). Developing artificial 3-D skeletal muscle tissues to investigate altered metabolic and functional dynamics in ME/CFS and Long COVID-19.

 

Watched the 3D muscle presentation. To my layman's ear it all sounded absolutely facinating. They seemed to have found loads of significant differences in how the muscle responds to ME and LC serum compared to controls, and also in gene expression. Obviously I'm not a scientist but I think this research looks very interesting and hopefully the paper will be out soon, I know the researcher said it was submitted when asked last autumn.

I would be interested to know if anyone else was watching and what they thought. I didn't make it through the questions so missed anything interesting said there.

 

Posted at the same time! I caught the 3d muscle seminar, inadequate summary above.