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Tweets from Bhupesh Prusty

Discussion in 'BioMedical ME/CFS News' started by Sarah94, Feb 1, 2020.

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  1. Mij

    Mij Senior Member (Voting Rights)

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    Deficits/disturbances of innate immune system can produce a wide range of disorders, including neuropsychiatric disorders.
     
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  2. Marky

    Marky Senior Member (Voting Rights)

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    Too bad. Seems to me more researchers should spend time getting constructive criticism, instead of clinging to own hypothesises. This is not directed at Prusty by the way, just a general advice that would probably move the field forward
     
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  3. Snowdrop

    Snowdrop Senior Member (Voting Rights)

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    While I've been on twitter in the past and it has it's uses - I think BP would be much better served presenting any hypotheses, requests, findings, thoughts etc here. Just my opinion though. ;)
     
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  4. ringding

    ringding Senior Member (Voting Rights)

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    I agree, but I guess we're biased!
    Still possible he might change his mind in future I suppose.
     
  5. dreampop

    dreampop Senior Member (Voting Rights)

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    I just don't see the need for a nonspecific hypothesis, but in any case you would think his research has been public and specific enough that his position is established in those areas. That and the me community is small and knowleadgable, we know what few researchers have contributed and try to champion them. Personally the grand statements are off-putting.

    Moving on, he asks about Eosinophlic Catanonic Protein in ME/CFS and people responded with some very specific published work

    https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1398-9995.1996.tb04570.x

    https://www.tandfonline.com/doi/abs/10.1300/J092v09n01_03
     
  6. FMMM1

    FMMM1 Senior Member (Voting Rights)

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    @Jonathan Edwards responded to a question I'd asked - haven't found Jonathan's post yet. Basically (from memory) he was highlighting that there is specialisation in T-cells e.g. MAIT cells are associated with mucosa. Jonathan was suggesting that a specialised class of T-cells, which were responsible for interpreting responses from other immune cells (command & control if you like), would produce something like that looks like ME. I.e. the system seems to be responding to a threat but it's actually responding to dysfunction in the command & control system.
     
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  7. Badpack

    Badpack Established Member (Voting Rights)

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    Prusty removed the complement pathway and the mitochondria went back to normal in his experiment. Thats a pretty big deal in my book tbh. I hope that ppl like Ron or alain moreau can recreate this with their Cfs model very soon. Definitely a lead that should be followed fast now.
     
  8. lunarainbows

    lunarainbows Senior Member (Voting Rights)

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    What’s the complement pathway?
     
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  9. Aslaug

    Aslaug Senior Member (Voting Rights)

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    The complement system are molecules that complement the immune system. They can bind to cells/microbes and act as targets for the immune system. Some of them can kill cells/microbes on their own.
     
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  10. wastwater

    wastwater Senior Member (Voting Rights)

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    Last edited: Jul 5, 2020
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  11. Andy

    Andy Committee Member & Outreach

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    Code:
    https://twitter.com/BhupeshPrusty/status/1314565018491539456


    Code:
    https://twitter.com/BhupeshPrusty/status/1314565019888168968


    Bit too much overly hopeful thinking in those tweets for my liking.
     
  12. NelliePledge

    NelliePledge Moderator Staff Member

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    Agreed - but still interesting. Timescale he’s talking about seems very short.
     
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  13. InitialConditions

    InitialConditions Senior Member (Voting Rights)

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    Indeed. It's hard for me to take him seriously, which is a shame because I'm sure he means well.
     
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  14. strategist

    strategist Senior Member (Voting Rights)

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    I don't see why someone couldn't put together a diagnostic test in a short amount of time, if they knew what the something in the blood is.

    How good the diagnostic test will be is another question and he is aware of that.
     
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  15. wastwater

    wastwater Senior Member (Voting Rights)

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    https://www.intechopen.com/books/a-...-angioedema-the-role-of-the-complement-system

    Looking through the paper above I discovered I may have a partial complement deficiency factor (I) at 4q25
    (A minor immune deficiency that you tend to grow out of)
    https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-7-42#:~:text= Characterization of new mutations and the first,the five families studied have complete... More

    https://nn.neurology.org/content/7/...GCyvmswY-PdwDcXDLtnKt_lAxUveIfH-p6z0WoPV2t59k
    aHUS atypical hemolytic uremic syndrome is mentioned in the paper above and is treated with Ravulizumab the new COVID trial drug
     
    Last edited: Oct 26, 2020
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  16. wastwater

    wastwater Senior Member (Voting Rights)

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  17. wastwater

    wastwater Senior Member (Voting Rights)

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    Maybe subtle immune complement deficiencies are widespread
    Are problems fighting bacteria in early life an indicator along with allergies(hay fever)
    Is it those with subtle complement deficiencies that get worse COVID and does that include long COVID
    I saw a trial using Eculizumab for severe COVID and wonder if it might be effective for long COVID (and ME)
     
    Last edited: Dec 1, 2020
  18. sebaaa

    sebaaa Established Member (Voting Rights)

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  19. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

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    skeptical of this. And this

     
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  20. Milo

    Milo Senior Member (Voting Rights)

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    Well, for the end of 2020 i will take the optimism and (metaphorically) run with it. It’s been a bad year and we need very good news soon...
     

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