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https://www.sciencedirect.com/science/article/pii/S0005796722002145
The relation between cognitive-behavioural responses to symptoms in patients with long term medical conditions and the outcome of cognitive behavioural therapy for fatigue – A secondary analysis of four RCTs
M.de Gier abgh
F.Picariello c
M.Slot a
A.Janse f
S.Keijmel e
J.Mentin gf
M.Worm-Smeitink f
H.Beckerman a
V.de Groot a
R.Moss-Morris c
H.Knoop dh
a
Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Rehabilitation Medicine, MS Center Amsterdam, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands
b
Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Medical Psychology, Amsterdam, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands
c
Health Psychology Section, Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, 5th Floor Bermondsey Wing, Guy's Campus, King's College London, UK
d
Amsterdam UMC Location University of Amsterdam, Department of Medical Psychology, Meibergdreef 15, 1105AZ, Amsterdam, the Netherlands
e
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands
f
Department of Medical Psychology, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands
g
Amsterdam Neuroscience Research Institute, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands
h
Amsterdam Public Health Research Institute, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands
Received 27 September 2022, Revised 15 November 2022, Accepted 12 December 2022, Available online 15 December 2022.
https://doi.org/10.1016/j.brat.2022.104243Get rights and content
Under a Creative Commons license
Open access
Highlights
•
Similar beliefs and behaviour moderate effect of CBT on fatigue across conditions.
•
The mediators of the effect of CBT on fatigue are also similar across conditions.
•
The findings support a transdiagnostic approach in the treatment of fatigue.
Abstract
Background
Cognitive behavioural therapy (CBT) is effective in reducing fatigue across long-term conditions (LTCs). This study evaluated whether cognitive and behavioural responses to symptoms: 1) differ between LTCs and 2) moderate and/or mediate the effect of CBT on fatigue.
Method
Data were used from four Randomized Controlled Trials testing the efficacy of CBT for fatigue in Chronic Fatigue Syndrome/ME (N = 240), Multiple Sclerosis (N = 90), Type 1 Diabetes Mellitus (N = 120) and Q-fever fatigue syndrome (N = 155). Fatigue severity, assessed with the Checklist Individual Strength, was the primary outcome. Differences in fatigue perpetuating factors, assessed with the Cognitive Behavioural Responses to Symptoms Questionnaire (CBRQ), between diagnostic groups were tested using ANCOVAs. Linear regression and mediation analyses were used to investigate moderation and mediation by CBRQ scores of the treatment effect.
Results
There were small to moderate differences in CBRQ scores between LTCs. Patients with higher scores on the subscales damage beliefs and avoidance/resting behaviour at baseline showed less improvement following CBT, irrespective of diagnosis. Reduction in fear avoidance, catastrophising and avoidance/resting behaviour mediated the positive effect of CBT on fatigue across diagnostic groups.
Discussion
The same cognitive-behavioural responses to fatigue moderate and mediate treatment outcome across conditions, supporting a transdiagnostic approach to fatigue.
Keywords
Chronic fatigue
Long term conditions
Cognitive behavioural therapy
Transdiagnostic
https://www.sciencedirect.com/science/article/pii/S0005796722002145
The relation between cognitive-behavioural responses to symptoms in patients with long term medical conditions and the outcome of cognitive behavioural therapy for fatigue – A secondary analysis of four RCTs
M.de Gier abgh
F.Picariello c
M.Slot a
A.Janse f
S.Keijmel e
J.Mentin gf
M.Worm-Smeitink f
H.Beckerman a
V.de Groot a
R.Moss-Morris c
H.Knoop dh
a
Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Rehabilitation Medicine, MS Center Amsterdam, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands
b
Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Medical Psychology, Amsterdam, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands
c
Health Psychology Section, Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, 5th Floor Bermondsey Wing, Guy's Campus, King's College London, UK
d
Amsterdam UMC Location University of Amsterdam, Department of Medical Psychology, Meibergdreef 15, 1105AZ, Amsterdam, the Netherlands
e
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands
f
Department of Medical Psychology, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands
g
Amsterdam Neuroscience Research Institute, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands
h
Amsterdam Public Health Research Institute, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands
Received 27 September 2022, Revised 15 November 2022, Accepted 12 December 2022, Available online 15 December 2022.
https://doi.org/10.1016/j.brat.2022.104243Get rights and content
Under a Creative Commons license
Open access
Highlights
•
Similar beliefs and behaviour moderate effect of CBT on fatigue across conditions.
•
The mediators of the effect of CBT on fatigue are also similar across conditions.
•
The findings support a transdiagnostic approach in the treatment of fatigue.
Abstract
Background
Cognitive behavioural therapy (CBT) is effective in reducing fatigue across long-term conditions (LTCs). This study evaluated whether cognitive and behavioural responses to symptoms: 1) differ between LTCs and 2) moderate and/or mediate the effect of CBT on fatigue.
Method
Data were used from four Randomized Controlled Trials testing the efficacy of CBT for fatigue in Chronic Fatigue Syndrome/ME (N = 240), Multiple Sclerosis (N = 90), Type 1 Diabetes Mellitus (N = 120) and Q-fever fatigue syndrome (N = 155). Fatigue severity, assessed with the Checklist Individual Strength, was the primary outcome. Differences in fatigue perpetuating factors, assessed with the Cognitive Behavioural Responses to Symptoms Questionnaire (CBRQ), between diagnostic groups were tested using ANCOVAs. Linear regression and mediation analyses were used to investigate moderation and mediation by CBRQ scores of the treatment effect.
Results
There were small to moderate differences in CBRQ scores between LTCs. Patients with higher scores on the subscales damage beliefs and avoidance/resting behaviour at baseline showed less improvement following CBT, irrespective of diagnosis. Reduction in fear avoidance, catastrophising and avoidance/resting behaviour mediated the positive effect of CBT on fatigue across diagnostic groups.
Discussion
The same cognitive-behavioural responses to fatigue moderate and mediate treatment outcome across conditions, supporting a transdiagnostic approach to fatigue.
Keywords
Chronic fatigue
Long term conditions
Cognitive behavioural therapy
Transdiagnostic