Open Scottsdale, AZ, USA - Long COVID hypoxia/hypercapnia intervention for brain fog

Non-invasive Treatment for Long COVID Brain Fog

'This study aims to assess the effects of both acute and chronic exposures to hypoxia and hypercapnia in patients with Long COVID syndrome.'

Mayo Clinic at Scottsdale, Arizona, USA

ClinicalTrials.gov
Mayo Clinic

 

Seems fairly bizarre.
Take a group of patients whose brains are struggling to work and mess about with their blood gases in ways that tend to make it difficult for brains to work.

 

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Crossover Assignment
Masking: None (Open Label)

Participant Group/Arm
Experimental: Acute exposure: Placebo, Progressive Carbon Dioxide, Intermittent Hypoxia

Study group will receive the three interventions in this order: Placebo, Progressive Carbon Dioxide, then Intermittent Hypoxia

Intervention/Treatment
Other: Acute Placebo Visit

• The placebo visit will include 6 simulated cycles of 5 minutes breathing 21% oxygen from a douglas bag and 5 minutes breathing room air.

Other: Acute Progressive Carbon Dioxide

• The progressive carbon dioxide visit will include a 60-minute progressive ramp which includes 6 cycles of progressive CO2 ramping starting at 0% and progressing up to 10% within 5 minutes immediately followed with 5 minutes of room air breathing in between cycles.

Other: Acute Intermittent Hypoxia

• The intermittent hypoxia exposure visit will include 6 cycles breathing 8-12% oxygen (O2) for 5 minutes with a target pulse oximeter saturation of 86-90%, followed by 5 minutes of breathing room air.