Researchers identify new target regulating mitochondria during stress

[darrellpf]

https://m.medicalxpress.com/news/2019-09-mitochondria-stress.html

 

[Snowdrop]

Here is the abstract to the relevant paper: https://ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.118.037968

 

[darrellpf]

This was the quote I found most interesting...

"Dr. Elrod's team also found that, while it can improve cell survival after heart injury, increased MCUB activity comes at the expense of mitochondrial energy production. "MCUB induction is a compensatory change," explained Dr. Elrod. Just like an emergency responder, MCUB moves in and tries to reduce cell death and aid cell survival—however, the reduction in mitochondrial calcium uptake is also maladaptive and limits the cell's ability to increase energy during stress."

Given current discussions about mitochonrdial complex V from Paul Fisher, Davis's studies about cellular energy production, etc, the paper seems very relevant to ME.

 

[darrellpf]

I sent Paul Fisher the link, along with a slight apology in case he'd already seen it.

It was amazing to get a quick reply along with a thanks for the heads up.