Review Research progress on the development and evaluation of animal models for chronic fatigue syndrome 2025 Feng et al

[Andy]

Abstract​

Chronic fatigue syndrome (CFS) is a debilitating multisystem disorder with an increasing prevalence, significantly impairing patients' quality of life. Several challenges remain, including unclear pathogenesis, the absence of specific diagnostic criteria, and limited therapeutic efficacy. Animal models play a crucial role in understanding the pathogenesis of CFS and testing potential therapies, necessitating the construction and evaluation of these models to be objective and scientifically rigorous. This study provides a comprehensive review of the methods for developing and assessing CFS models, analyzes their strengths and limitations, identifies key challenges in current research, and guides the development of clinically relevant CFS animal models.

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[Jonathan Edwards]

Research regress on the development...

 

[Utsikt]

How is producing generic symptoms in mice relevant for studying the disease mechanic of ME/CFS?

It’s like saying that this fatigued mouse is a good model for studying MS because people with MS often experience fatigue.