Rapamune / mTOR podcast

Discovered on Easter Island, rapamycin has a unique history and impacts the mTOR pathways in our bodies.

mTOR is like a general contractor in sensing nutrients and regulating homeostasis in all cells.

The chat touches on ME-related things like how mTOR senses ATP, keto diets, methionine, diabetes, longevity.

Fwiw, I've been taking Rapamune, an mTOR inhibitor, since November. Its doubled my capacity: I can now walk up 2 flights of stair in a row.

After hearing the Sabatini interview, I have reduced my daily 1mg to every other day.

STEM Talk podcast: https://itunes.apple.com/ca/podcast/stem-talk/id1091402153?mt=2

From the podcast:

...describes David Sabatini’s discovery of mTOR ...gives us a first-hand account of how his research into rapamycin in 1994 as a graduate student led him to the discovery of mTOR, which we now know is a critical regulator of cellular growth.

Our interview with David delves into his continuing research into mTOR, which has led to promising opportunities for the development of new treatments for debilitating diseases such as cancer, diabetes and neurological disorders. He also discusses mTOR’s role in healthspan and lifespan.

David is a molecular cell biologist who, according to Reuters News Service, is on the short list for a Nobel Prize. David is on the faculty at MIT and heads up the Sabatini Lab at the Whitehead Institute.

In today’s episode, we discuss:
Rapamycin, a macrolide antibiotic discovered in the soil of Easter Island David’s discovery of mTOR while a grad student at Johns Hopkins mTOR’s role as one of the major growth pathways in the body mTOR’s role as a nutrient sensor How mTOR inhibiton has become one of the hottest topics in longevity research mTOR’s role in diseases, especially its connection to cancer The role of RAG GTPases as key mTOR mediators Protein intake and downstream mTOR activation Research into ketogenic diets effect on longevity and healthspan Whether David would take rapamycin as a means to enhance his longevity And much, much more