Chandelier
Senior Member (Voting Rights)
Pre-COVID-19 body mass index and post-acute cardiovascular, gastrointestinal, and neuropsychiatric outcomes among children and young adults with SARS-CoV-2 infection: An EHR-based cohort study from the RECOVER Initiative
• Pre-infection severe obesity was associated with higher risks of cardiovascular and gastrointestinal disorders.
• Neuropsychiatric associations were heterogeneous after covariate adjustment.
• Findings support cautious BMI-informed post-COVID risk assessmentin youth.
We aimed to evaluate the association between pre-COVID-19 BMI status and post-acute cardiovascular, gastrointestinal, and neuropsychiatric outcomes in children and young adults.
Pre-infection BMI was defined using measurements obtained within 18 months before the index date and categorized as healthy weight, overweight, obesity, or severe obesity; when multiple values were available, the most recent measurement was selected.
We assessed incident post-acute cardiovascular, gastrointestinal, and neuropsychiatric symptoms and conditions occurring 28 to 179 days post-infection.
Adjusted relative risks (RRs) were estimated using modified Poisson regression models, comparing elevated BMI categories to the healthy weight.
Severe obesity was also linked with increased risks of diarrhea (adjusted RR 1.34; 95% CI 1.10–1.64) and gastroesophageal reflux disease (adjusted RR 1.29; 95% CI 1.06–1.58).
Associations between BMI and neuropsychiatric outcomes were heterogeneous, with inverse associations observed for some conditions, including anxiety and major depression.
Association between pre-infection BMI and neuropsychiatric outcomes was more variable and should be interpreted with caution.
These findings suggest BMI-stratified post-COVID-19 monitoring strategies may help inform long-term care in youth.
Web | DOI | Journal of Infection
Zhou, Ting; Zhang, Bingyu; Zhang, Dazheng; Jhaveri, Ravi; Chen, Jiajie; Becich, Michael J.; Castro, Leah; Chen, Yu; Chilukuri, Nymisha; Herring, Sharon J.; Lei, Yuqing; Li, Lu; Lu, Yiwen; Hornig, Maxwell; Khalsa, Amrik Singh; Liebovitz, David; Mosa, Abu Saleh Mohammad; Taylor, Bradley W.; Tedla, Yacob G.; Thodeson, Drew; Tong, Jiayi; Wu, Qiong; Forrest, Christopher B.; Chen, Yong
Highlights
• This large multicenter cohort included 139,320 youth (5–20 years) with SARS-CoV-2 infection.• Pre-infection severe obesity was associated with higher risks of cardiovascular and gastrointestinal disorders.
• Neuropsychiatric associations were heterogeneous after covariate adjustment.
• Findings support cautious BMI-informed post-COVID risk assessmentin youth.
Summary
Objectives
Post-acute sequelae of SARS-CoV-2 infection (PASC) can affect multiple organ systems, but the role of preinfectional body mass index (BMI) in these outcomes among children and young adults remains unclear.We aimed to evaluate the association between pre-COVID-19 BMI status and post-acute cardiovascular, gastrointestinal, and neuropsychiatric outcomes in children and young adults.
Methods
We conducted a retrospective cohort study using data from 139,320 individuals aged 5 to 20 years with confirmed SARS-CoV-2 infection between March 2020 and September 2023 across 20 U.S. pediatric health systems participating in the RECOVER Initiative.Pre-infection BMI was defined using measurements obtained within 18 months before the index date and categorized as healthy weight, overweight, obesity, or severe obesity; when multiple values were available, the most recent measurement was selected.
We assessed incident post-acute cardiovascular, gastrointestinal, and neuropsychiatric symptoms and conditions occurring 28 to 179 days post-infection.
Adjusted relative risks (RRs) were estimated using modified Poisson regression models, comparing elevated BMI categories to the healthy weight.
Findings
Among 139,320 participants (mean [SD] age, 13.0 [4.3] years; 51.6% female), severe obesity was associated with a higher risk of cardiovascular disorders (adjusted RR 2.56; 95% CI 1.93–3.41), particularly hypertension (adjusted RR 3.68; 95% CI 2.65–5.11).Severe obesity was also linked with increased risks of diarrhea (adjusted RR 1.34; 95% CI 1.10–1.64) and gastroesophageal reflux disease (adjusted RR 1.29; 95% CI 1.06–1.58).
Associations between BMI and neuropsychiatric outcomes were heterogeneous, with inverse associations observed for some conditions, including anxiety and major depression.
Interpretation
In this cohort study, pre-COVID-19 BMI status was associated with the risk and pattern of post-acute cardiovascular and gastrointestinal outcomes among children and young adults.Association between pre-infection BMI and neuropsychiatric outcomes was more variable and should be interpreted with caution.
These findings suggest BMI-stratified post-COVID-19 monitoring strategies may help inform long-term care in youth.
Web | DOI | Journal of Infection