Post COVID Migraine in a Six Day Cycle

Hutan said:
When I was getting lot of cramps, I bought a magnesium product that was supposed to be absorbed through the skin. I then spent some time looking at the evidence for transdermal Mg absorption. Turned out, there was not much evidence to support the idea of delivering magnesium via the skin. The evidence is contested, but from what I've seen, the studies suggesting that there is significant magnesium uptake tend to come from organisations with an interest in promoting a transdermal magnesium product.

Myth or Reality—Transdermal Magnesium? 2017


Maybe a warm foot bath helps with blood circulation, or even just extra rest and muscle relaxation, and those things might impact on a migraine?
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I also had a look at studies on transdermal absorption when I was initially looking into this and IIRC there were quite a lot of contradictory ones but in the end I landed on it sounding as though there was reasonable absorption particularly if the concentration of Mg in the water is high, and if the water is warm. I didn't look into conflicts of interest, though, so maybe your assessment of the literature was better than mine! :)

However, any impact on blood circulation is going to be very temporary, and I don't find the baths restful - quite the opposite, because I have to remain sitting, and I'm no more relaxed than when I don't have my feet in a bath - I just carry on doing whatever I'd be doing otherwise (eating, reading, watching the TV, writing on the computer). And I find the effects to be cumulative over periods of weeks. So going by my experience, I think there's something in it, but N=1, possible misattribution, etc. etc.
 
Something strange has just happened which is semi miraculous so I thought I ought to make a note about it here.

In relation to the diabetes 2 like symptoms, which I believe are cause by RAS imbalance cause by covid, my legs have been swelling periodically with oedema which is typical of diabetes 2 and is cause by insufficient blood flow due to issues with poor vasodilation, which is exactly what happens when RAS is out of whack because AngiotensinII is not being converted by ACE2 receptors into vasodilating messengers because covid has nobbled all the ACE2 receptors.

I have been troubled by leg oedema for 6 days. So took a look in my diary to study my records of previous occurrences. After trying to look for causes and finding nothing I had an inspiration to look at the end of oedema episodes and see if there were any prospective cures I had not recognised.

Beetroot juice presented itself, which is something I have tried because of its high nitrate content which can in theory facilitate nitric oxide production which can assist vasodilation. I had not recognised it as having had an effect previously though my diary showed that a dose of it was coincident with the end of previous oedema episodes. So I tried it again today and within an hour my leg oedema of six days had gone down and I am quite pleased about this as it was concerning. I was very surprised it worked so well and do not think it is a coincidence.

Just thought I would pass it on in case it can help someone else.
 
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boolybooly said:
Beetroot juice presented itself, which is something I have tried because of its high nitrate content which can in theory facilitate nitric oxide production which can assist vasodilation. I had not recognised it as having had an effect previously though my diary showed that a dose of it was coincident with the end of previous oedema episodes. So I tried it again today and within an hour my leg oedema of six days had gone down and I am quite pleased about this as it was concerning. I was very surprised it worked so well and do not think it is a coincidence.

Just thought I would pass it on in case it can help someone else.
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Interesting, because beetroot gives me killer migraines!
 
Despite working hard to reduce blood glucose and insulin overproduction causing acanthosis nigricans, I am still getting peripheral neuropathy in the medial plantar and lateral plantar nerves (terminal branches of the tibial nerve), creating sensations in my toes.

As previously stated, I believe this is due to covid becoming recurrent, (like many viruses before it, due to my immune dysfunction), resulting in the depletion of ACE2 receptors, leading to excess unprocessed angiotension II, resulting in renin angiotensin system imbalance at default levels of functionality. i.e. insulin resistance, vasoconstriction, proteinurea etc.

I found this blog interesting. It is one of a series of blogs by Lisa Sanders MD at Yale.
www.yalemedicine.org

When Nerve Pain and Numbness Are Linked to Long COVID

Clinicians have recently identified peripheral neuropathy in some Long COVID patients.
www.yalemedicine.org www.yalemedicine.org
Why would COVID-19 cause peripheral neuropathy?
Lindsay McAlpine, MD, a neurologist and founder of the Yale NeuroCOVID Clinic, has conducted research on what is now known clinically as peripheral neuropathy after COVID-19. She notes that there are two main categories of neuropathy following COVID-19 infection. One is the “acute illness mediated type,” in which patients find themselves with sudden, severe neuropathy, generally around the same time as their active illness. The second is small fiber neuropathy, which results from damage to the thinnest, unmyelinated nerves in our body and often begins with burning pain in the feet. It typically arises somewhat later—around two to 12 weeks post-illness.

Peripheral neuropathy in COVID-19 patients has been reported in both axonal and demyelinating forms, according to the medical literature. Researchers suspect that COVID-19 associated neuropathy could be driven by several causes. One might be immune system dysfunction, in which the body attacks itself instead of, or in addition to, attacking viral particles. Or COVID-19 may have hemodynamic effects that interfere with how blood flows through the body’s blood vessels, damaging the nerves and leading to “ischemia” due to restricted blood/nutrient flow, known as critical illness neuropathy.
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