Odds that one specific JAK drug could “work” for ME/CFS but others not at all?

[Jaybee00]

Obviously I’m aware that the various JAK drugs have different affinities for different receptors 1/2/3, etc., but how likely might it be that only one specific JAK drug “works” for ME/CFS and the others basically not at all?

 

[Creekside]

Is that a question of whether a specific drug will work for ME for one specific individual, or for PWME in general? PWME seem to have wildly different responses to treatments. Cuminaldehyde worked marvelously for me, but hasn't had a similar effect on anyone else.

So, my guess is that as with most ME treatments, a specific JAK drug might work well for one person, make some other person worse, and have no effect on the majority.

 

[Jaybee00]

for PWME in general