Open Norway: Plasma cell aimed treatment with daratumumab in ME/CFS - Haukeland University Hospital

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The framework of thinking about mechanisms is shifting about quite a bit at the moment. I have always respected the Norwegians' commitment and rigour but been uncertain about the justification for pursuing daratumumab. My thought now is that this is a key avenue to explore and I would strongly recommend supporting their work.
 
The framework of thinking about mechanisms is shifting about quite a bit at the moment. I have always respected the Norwegians' commitment and rigour but been uncertain about the justification for pursuing daratumumab. My thought now is that this is a key avenue to explore and I would strongly recommend supporting their work.
What has changed your mind? DecodeME?
 
What has changed your mind? DecodeME?

Not especially. More than anything the robust discussions we have had here. @ryanc97 was arguing that the daratumumab 'responses' must be real. That is easily rebuffed, but the more I look at those data the more I think the supporting immunology makes them look real. And if I talked to the patients I might also think they could not all be deluded or lucky. Then I started thinking about other ways daratumumab might be working that made the inconsistency of all the trials look less impenetrable.

I think it may be a good example of how in science you should not be too bothered if your first theory was wrong if you start getting results that look worth following up. You turn the block of jigsaw pieces that did fit together upside down and see if that helps. At some point you may find you have a treatment that works well enough that that becomes more important than your theorising. And a bit later with luck you begin to see what is really going on.
 
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