https://www.medscape.com/viewarticle/new-data-most-promising-treatments-long-covid-2024a1000lm5 No need to read this—I promise! (Might need to logon to medscape).
New Data: The Most Promising Treatments for Long COVID · Low-Dose Naltrexone · Selective Serotonin Reuptake Inhibitors (SSRIs) and Antidepressants. I can't log in but this is what it said on google search "5 hours ago".
That probably rules it out for ME, since many of us have tried LDN and SSRIs and antidepressants ... with no beneficial effects. Also, whichever treatment is proposed, I expect there will be at least a couple of stories about "it worked for me!", of course lacking in evidence that they had ME or that there was a real benefit.
I am om both SSRI and LDN and yet I’m still severe and bedbound. These meds don’t even scratch the surface, I don’t know why scientists keep talking about them.
And it's possible that the particular SSRI sertraline/Zoloft may be contributing to mitochondrial dysfunction in some.
Yikes. What a sorry state of affairs. Literally all things that were discussed long before LC, none of which work. Low-Dose Naltrexone SSRIs Modafinil Metformin Antihistamines Well, aside from metformin, but none of those is in any way promising. Not even close. All shows how medicine is only able to do anything once they know the cause of a problem. Without that, there really is no shortcut. It's like trying to brute force modern encryption, it would take trillions of years just to get a single hit by chance, and even then. So really the entire industry of evidence-based medicine should be closed down and everything repurposed on basic research and developing technologies to get further ahead. The rest is completely useless, this much has been made clear. But instead we are literally heading fast the other way. Aaaaargh!
It seems that some T2 diabetes drugs such as Metformin and GLP-1 agonists are showing promise for other health conditions.
I'd add the cytokine therapies to the list. It seems more like playing downstream whack-a-mole. In general, anything that reduces inflammation probably has a good effect though often those effects likely don't last. My analogy is coming home and finding your house has been trashed with a drinking party while you were away on vacation. All sorts of experts will come in and examine the damage. The bottle expert will note unusually high levels of bottles and will propose a schedule to speed up their recycling. The hardwood people will note all the floors are unusually scraped, etc. The cause may be that you posted that were going to be away on social media, or that your teenager let their friends know. You may not find the cause but the "bottle therapy" will make you feel better until the problem happens again. All the clues about the downstream damage are very useful. It takes just the right, often incidental clue, to locate the cause and come up with a good solution.
From my own observation is that some of these medications work short-term for some pwME and then stop working.
I was on SSRI for other reasons for the several years I had undiagnosed mild ME if it had any beneficial effect I wouldn’t have got worse and get diagnosed.
