Neurologic Effects of SARS-CoV-2 Transmitted among Dogs, 2023, Kim et al

[EndME]

Neurologic Effects of SARS-CoV-2 Transmitted among Dogs

Abstract
SARS-CoV-2 induces illness and death in humans by causing systemic infections. Evidence suggests that SARS-CoV-2 can induce brain pathology in humans and other hosts. In this study, we used a canine transmission model to examine histopathologic changes in the brains of dogs infected with SARS-CoV-2.

We observed substantial brain pathology in SARS-CoV-2–infected dogs, particularly involving blood–brain barrier damage resembling small vessel disease, including changes in tight junction proteins, reduced laminin levels, and decreased pericyte coverage. Furthermore, we detected phosphorylated tau, a marker of neurodegenerative disease, indicating a potential link between SARS-CoV-2–associated small vessel disease and neurodegeneration.

Our findings of degenerative changes in the dog brain during SARS-CoV-2 infection emphasize the potential for transmission to other hosts and induction of similar signs and symptoms. The dynamic brain changes in dogs highlight that even asymptomatic individuals infected with SARS-CoV-2 may develop neuropathologic changes in the brain.

https://wwwnc.cdc.gov/eid/article/29/11/23-0804_article#suggestedcitation

 

[rvallee]

Bold take but I think there may be something to that germ theory of disease thing, and that isn't a simple "pathogen X can only cause disease-Y-caused-by-pathogen-X", or whatever arbitrary combination of ideas is currently accepted.

I wonder if there's a point back in time when this could have happened correctly, or if decades of pervasive refusal and slow-and-begrudging acceptance, with every single step fought and resisted, was inevitable because of some quirk in how human intelligence works, how greed and short-term self-interest dominate all human affairs.

Because then there's the whole array of chemicals and pollutants that also cause disease and have largely been brushed aside in favor of psychosocial/lifestyle explanations to the point of advising people to go out and breathe in highly polluted air as much as they can. Microplastics and other chemicals have been found all over people's bodies, and it's still not taken seriously, barely researched because it's politically forbidden.

Just to think if there had been some principle about being precautionary about these things, or some wild hippie idea like this, instead of healthcare mostly serving industrial and economic policies. Ah, one can dream.

 

[Ash]

Yeah…It’s exhausting isn’t @rvallee?

Although, I don’t think it’s human nature so much as the nature of a certain specific type of human. Those that through violence of one variety or another other, have got to the top. A few who now subject the rest of us to the physical fall out of their horrible vision of domination. Supported by a larger cohort, the go along to get along type of human.