Microbiome-encoded bile acid metabolism modulates colonic transit times, 2021, Li et al

Andy

Senior Member (Voting rights)
In mice.

Highlights

  • Gut microbiome-generated bile acids regulate colonic transit via TGR5.
  • Lithocholic acid had the largest colonic pro-motility effect.
  • Bile acids exert sex-biased effects on gut transit times.
  • Enteric nervous system transcriptional responses are regional and microbiome-specific.
Summary

Gut motility is regulated by the microbiome via mechanisms that include bile acid metabolism. To localize the effects of microbiome-generated bile acids, we colonized gnotobiotic mice with different synthetic gut bacterial communities that were metabolically phenotyped using a functional in vitro screen. Using two different marker-based assays of gut transit, we inferred that bile acids exert effects on colonic transit. We validated this using an intra-colonic bile acid infusion assay and determined that these effects were dependent upon signaling via the bile acid receptor, TGR5. The intra-colonic bile acid infusion experiments further revealed sex-biased bile acid-specific effects on colonic transit, with lithocholic acid having the largest pro-motility effect. Transcriptional responses of the enteric nervous system (ENS) were stereotypic, regional, and observed in response to different microbiota, their associated bile acid profiles, and even to a single diet ingredient, evidencing exquisite sensitivity of the ENS to environmental perturbations.

Open access, https://www.cell.com/iscience/fulltext/S2589-0042(21)00476-4
 
i will just eat three mice a day to get my digestive system on track . sorry could not resist . interesting paper though could be the basis for new drugs considering the ever increasing rates of digestive problems in modern societies .
 
Not to judge but I doubt that eating 3 mice per day makes for a healthy diet unless you're a cat.
 
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