Medically unexplained symptoms (MUS): primary care intervention - Leavis,Parry,Stevenson,Booth,Scope,Davis,Ren,Sutton, P. White,Moss-Moriss,Buszewicz

Sly Saint · Jul 27, 2019

Have set this up on a thread on it's own (was previously on https://www.s4me.info/threads/mus-services-in-uk-and-other-mus-related-issues.8318/ )
University of Sheffield.

Funding details:
Funding: National Institute of Health Research (NIHR) Health Technology Assessment (HTA) Programme (evidence synthesis)

Call: 14/26 Medically unexplained symptoms (MUS): primary care intervention

Start date: 01/09/2015 End date: 28/02/2017 (18 months)

Total Research costs: £200,007.67

Chief Investigator: Dr Joanna Leaviss

Organisation: ScHARR, University of Sheffield
Click to expand...

https://www.sheffield.ac.uk/scharr/sections/heds/mus/info

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=25520

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=4&cad=rja&uact=8&ved=2ahUKEwjd4KPU-dTgAhU6VxUIHW8pBp4QFjADegQIBhAC&url=https://njl-admin.nihr.ac.uk/document/download/2007338&usg=AOvVaw03jEe_b-20sZFMPNGgEu3A

Doing a bit more digging on this systematic review done at Sheffield.
Coyne wrote a detailed blog about it in 2016
https://jcoynester.wordpress.com/20...rventions-for-medically-unexplained-symptoms/

it ends with this line
"Consumers and taxpayers are put at risk from biased evaluations of interventions which will undoubtedly affect health policy decisions."

It was discussed on PR (before my time)
https://forums.phoenixrising.me/threads/£208-000-of-taxpayers-money-for-a-group-incl-peter-white-rona-moss-morris-to-review-mus-evidence.39746/
Click to expand...

I wrote to Joanna Leavis to ask a few questions.
It was treated as an FOI and had this reply:

I write in response to your request for information to Dr Joanna Leavis. As you are no doubt aware, all requests for information made to Public Authorities as defined in the Freedom of Information Act should be regarded as being made under the requirements of that Act, and so your request has been passed to me.
The University's responses to your questions follow:
RE:
14/26 Medically unexplained symptoms (MUS): primary care intervention: please could you tell me if this review has finished

(according to protocol it finished in 2017 but PROSPERO says the review is ongoing).
This study is on-going.

Have the results been published? If so, where.
No, but they will be published as an HTA monograph in due course

Could you also tell me which charities were represented in the Expert advisory group?.
This information will be included in the published study and is therefore exempt from disclosure at the current time under Section 22 of the Freedom of Information Act (information intended for future publication)..

I am required under the Act to inform you that if you have cause for genuine complaint regarding our reply to your request for information, you should within 60 days of receiving this response, write to the University FOI Unit, The University Secretary’s Office, Sheffield University, Western Bank, Sheffield S10 2TN or email foi@sheffield.ac.uk explaining why you are not satisfied with the result.

If you still remain unsatisfied with the University's decision, you will be entitled to complain to the Information Commissioner, Wycliffe House, Water Lane, Wilmslow, Cheshire SK9 5AF.

Yours sincerely

Anne Cutler

The University Secretary’s Office

University of Sheffield

Western Bank

Sheffield

S10 2TN
Click to expand...

estimated publication date of this study is now Nov 2019

Sly Saint · Nov 2, 2019

Latest project information

Medically unexplained symptoms(MUS): primary care intervention
Project title: Medically unexplained symptoms(MUS): primary care intervention

Call to action: 14/26 14/26 Medically unexplained symptoms (MUS): primary care intervention

Research type: Evidence Synthesis

Chief investigator: Dr Joanna Leaviss orcid.org/0000-0002-5632-6021

Contractor: The University of Sheffield

Cost: £212,436.22

Co-investigators: Dr Alison Scope, Dr Andrew Booth, Dr Marta Buszewicz, Dr Shijie Ren, Ms Andrea Shippam, Ms Anthea Sutton, Ms Sarah Davis, Professor Glenys Parry, Professor Matt Stevenson, Professor Peter White, Professor Rona Moss-Morris.

Started: September 2015 | Status: Waiting to publish

PROSPERO registration: CRD42015025520

Click to expand...

https://www.journalslibrary.nihr.ac.uk/programmes/hta/142608/#/

https://www.journalslibrary.nihr.ac.uk/search/#/?search=14/26 Medically unexplained symptoms (MUS)* primary care intervention&sitekit=true&indexname=full-index&task=search&selected_facets=

Health Technology Assessment Estimated Publication Date: Mar 2020

eta: original publication was due in 2017(?) why the massive delay? and new publication date very close to ME NICE guidelines publication.

@dave30th

anyone in contact with Coyne, and Keith Geraghty.

Esther12 · Nov 2, 2019

Sly Saint said: ↑

Latest project information

https://www.journalslibrary.nihr.ac.uk/programmes/hta/142608/#/

https://www.journalslibrary.nihr.ac.uk/search/#/?search=14/26 Medically unexplained symptoms (MUS)* primary care intervention&sitekit=true&indexname=full-index&task=search&selected_facets=

Health Technology Assessment Estimated Publication Date: Mar 2020

eta: original publication was due in 2017(?) why the massive delay? and new publication date very close to ME NICE guidelines publication.
Click to expand...

Maybe they wanted to see how things shook out with Larun, the HRA, etc? Maybe they now feel they have cover for ignoring the problems with this research? Or I guess sometimes things just get delayed?

I does look like a ridiculous piece of research if they're just interested in how to manipulate the way people fill in QoL questionnaires.

Sly Saint · Apr 17, 2020

Am putting this screen shot here as I think this has 'disappeared' (£212,000 worth).

the link above
14/26 Medically unexplained symptoms (MUS): primary care intervention

initially takes you to this

but if you then click any of the tabs.......it seems to disappear.

(could someone else check it as it might just be my pc/browser whatever)

Esther12 · Apr 17, 2020

That page seems weird to me, but this one says 'status: waiting to publish':

https://www.journalslibrary.nihr.ac.uk/programmes/hta/142608/#/

Sly Saint · Jul 26, 2020

Abstract
The term MUS is used to cover a wide range of symptoms which cannot clearly be explained by a general medical condition, even after a thorough examination and any relevant investigations.

A UK MUS prevalence rate of 18% of consecutive attenders to UK GP practices has been estimated (Taylor et al 2012).

MUS costs the UK NHS in excess of £3.1 billion per annum and taking into account quality of life and sickness absence, wider costs to the economy reach £14 billion annually (Bermingham et al. 2010).

A range of pharmacological, psychological and physical therapies have been implemented in the treatment of MUS. Behavioural Modification Interventions such as Cognitive Behavioural Therapy (CBT), Graded Exercise Therapy (GET), and behaviour therapies are commonly delivered in primary care.

We will conduct a systematic review, using rigorous methods, of the evidence on the clinical, cost-effectiveness and acceptability of behavioural modification interventions for MUS in primary care and community-based settings.

Search strategy: we will conduct a comprehensive search of bibliographic databases, combining terms for MUS and related synonyms and primary care setting. Searches will not be limited by intervention as we anticipate overlap between interventions and inconsistencies in labels and definitions.

Methodological search filters will be applied to identify systematic reviews, RCTs, and qualitative research and cost-effectiveness where appropriate. Inclusion criteria: Intervention interventions that aim to modify behaviour will be included. These include CBT, GET, behaviour therapies.

Where the intervention is not explicitly behaviour modification, we will adopt a broad inclusion criteria, with studies included if i) at least one primary outcome is a functional or behavioural change measure, or ii) the stated explicit aim of the intervention is to change behaviour. Population studies of populations meeting the criteria for MUS, MUPS, or somatoform disorders. Functional somatic syndromes will be included. Setting studies in primary care or community-based settings.

Design Randomised Controlled Trials. Comparator usual care, treatment as usual, or wait list, trials with a placebo control. We will also include head to head trials. Outcomes improvement in symptoms, functioning and/or health related quality of life; use of healthcare resources.

Quantitative synthesis: a random effects network meta-analysis will be used, providing the relevant RCTs form a network of evidence. The random effects pairwise comparison will allow heterogeneity in treatment effects across studies. Random effects pairwise meta-analysis will be performed when data do not form a network.

Qualitative synthesis: A realist synthesis will be conducted to provide added value to the quantitative synthesis by indicating patient and service provider issues around the acceptability of interventions. Thematic synthesis will be used to aggregate the findings.

Cost-effectiveness: evidence on cost-effectiveness will be identified by conducting a systematic review of existing economic analyses, and undertaking a de novo model based evaluation where there is a lack of relevant existing analyses. Costs will be evaluated from an NHS and personal social services perspective.

Health benefits will be estimated using quality-adjusted life years (QALYS) gained. Future costs will be discounted at 3.5% in line with NICE's current guidance.
Click to expand...

@dave30th
could you take a look at/chase this up

Log in or Sign up

Medically unexplained symptoms (MUS): primary care intervention - Leavis,Parry,Stevenson,Booth,Scope,Davis,Ren,Sutton, P. White,Moss-Moriss,Buszewicz

Sly Saint Senior Member (Voting Rights)

Sly Saint Senior Member (Voting Rights)

Esther12 Senior Member (Voting Rights)

Sly Saint Senior Member (Voting Rights)

Esther12 Senior Member (Voting Rights)

Sly Saint Senior Member (Voting Rights)

Share This Page

Log in or Sign up

Medically unexplained symptoms (MUS): primary care intervention - Leavis,Parry,Stevenson,Booth,Scope,Davis,Ren,Sutton, P. White,Moss-Moriss,Buszewicz

Sly Saint Senior Member (Voting Rights)

Sly Saint Senior Member (Voting Rights)

Esther12 Senior Member (Voting Rights)

Sly Saint Senior Member (Voting Rights)

Esther12 Senior Member (Voting Rights)

Sly Saint Senior Member (Voting Rights)

Share This Page

Useful Searches