Is this posted somewhere already? https://twitter.com/user/status/1918337911264825734 Update on Patient #1 in Our Pemgarda + Paxlovid Case Study Six days ago, the first patient in our case series received a combination treatment of Pemgarda monoclonal antibodies and Paxlovid, under the care of his physician. We know so many of you are curious as to how he’s doing - here’s his symptom update: ***** “Since the first Pemgarda infusion, I've observed an 80% reduction in brain fog, a 50–70% improvement in sleep quality, and a similar reduction in chronic inflammation-related symptoms. However, post-exertional malaise has significantly worsened in the week following treatment. Light activities that were previously tolerable now trigger a PEM crash. Not clear if this represents a temporary response related to immune system activity following antibody infusion, will continue to monitor and share updates.” ***** Our team is cautiously optimistic about the possible results of this treatment - although it’s still too early to gauge the long-term outcome. We’re very glad to hear about the patient's 80% reduction in Long COVID brain fog, which seems quite significant. As for his post-exertional malaise (or PEM for short), the patient will continue to monitor this closely. While the causes of PEM are not yet well understood, research gets closer every day to uncovering the cause- and we hope our work will add to that. Although we can’t yet say for sure, it’s indeed possible that this symptom marks changes associated with the therapeutic mechanism of action of the drug.
https://twitter.com/user/status/1912841063351361613 It’s happening. The first patient in our case studies got his pre-treatment blood work done this week! We sent a mobile phlebotomist to his home to collect the sample, saving him the trip to the lab. We know how difficult it can be for very severe home- and bedbound patients to make it to a medical facility. So we designed our protocol to be as easy for patients as possible. Patient #1’s blood will be sent off to our laboratory facility in southern California. We’ll be running several tests on it - including transcriptomics, a cutting-edge technique that we believe holds huge potential for detecting persistence of the SARS-Cov-2 virus. The persistence of the SARS-Cov-2 virus is what we believe to be the leading hypothesis for the root cause of Long COVID. Treating this chronic infection is what cured our founder @rd108, and we believe this could be the answer for so many suffering. ❤️ The transcriptomics test will allow us to quantify SARS-Cov-2 RNA and the associated inflammatory gene signatures in blood. This means we’re measuring both signs of the virus itself, as well as changes in the patient’s immune response that would show the virus is still there. We’ll be measuring these markers before and after treatment, and we expect the abnormal markers will begin to return to normal, if the treatment is successful! ✨ We’ll also be running additional labs, both for the purposes of safety monitoring, as well as to see if we can validate some of the existing research that’s been done on Long COVID biomarkers. (More info on that to come!). Our team is incredibly excited to finally get these biomarker tests up and running! Patient #1 will be receiving his treatment next week. We can’t wait to see where things go! (Tweets out of sequence)
PEM got worse Claiming success I mean maybe the PEM will get better down the line but as someone with terrible brain fog i would not trade any improvement in that for worsened PEM.
