LEUKOENCEPHALOPATHY, DISCONNECTION, AND COGNITIVE NEUROSCIENCE (2013) Filley

[wastwater]

https://touchneurology.com/leukoencephalopathy-disconnection-and-cognitive-neuroscience/
Multiple sclerosis (MS) is the most familiar CNS white matter disease of adults, but is just one of more than 100 clinical entities in which white matter is prominently or exclusively affected.3 Genetic, demyelinative, infectious, inflammatory, toxic, metabolic, vascular, traumatic, neoplastic, and hydrocephalic disorders may all produce leukoencephalopathies, and, remarkably, some form of neurobehavioral impairment has been associated with every disorder previously described.

 

[Cheshire]

Abstract

Leukoencephalopathy refers to disorders of brain white matter. Neurologists have long appreciated the importance of white matter in the normal function of the central nervous system (CNS), and much is known of the effects of white matter lesions on motor and sensory systems.The impact of white matter damage on higher cerebral functions is at least as important, and the concept of disconnection has been invoked to conceptualize the disruption of higher brain operations by damage to white matter tracts linking gray matter areas