Just thought I'd share this. My immunologist (who seems to really know his stuff) has just prescribed Zantac for me. I thought, "That's weird, isn't that for gastric problems?". Well, apparently, only recently, Zantac was discovered to be an IL6 (interleukin 6) inhibitor. IL6 is the cytokine most involved in raised CRP. Its one of the cytokines whose levels peak several hours after exertion (so it might be a player in postexertional malaise). My CRP is elevated most of the time, so the drug seems a good fit for me. Not sure about others whose CRP isn't raised (many might not know if theirs is raised, especially if they're never been tested at their worst). Here's a study showing Zantac's effects on IL6: Ranitidine reduces postoperative interleukin-6 induced C-reactive protein synthesis. I'll post back about whether it has any effect on my symptoms. Even if it does, I guess the question is, would it have any effect on those whose CRP isn't raised?