Insights into Metabolite Diagnostic Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2021, Yamano et al

Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating fatigue, with/without infectious or neuropsychiatric symptoms, and with a minimum duration of 6 consecutive months. Its pathogenesis is not fully understood. There are no firmly established diagnostic biomarkers or treatment, due to incomplete understanding of the etiology of ME/CFS and diagnostic uncertainty. Establishing a biomarker for the objective diagnosis is urgently needed to treat a lot of patients. Recently, research on ME/CFS using metabolome analysis methods has been increasing. Here, we overview recent findings concerning the metabolic features in patients with ME/CFS and the animal models which contribute to the development of diagnostic biomarkers for ME/CFS and its treatment. In addition, we discuss future perspectives of studies on ME/CFS.

Open access, https://www.mdpi.com/1422-0067/22/7/3423/htm

 

They seem to be referencing quite a wide range of studies into both animals and humans over a wide time period. No doubt there’s lots of differing criteria for people included in these studies, it would have perhaps been useful if they’d grouped the findings based upon these criteria as well as bundling them all together.

Update: I tried to get an LLM (ChatGPT in this case) to do this, I’d be wary of accuracy as it made mistakes along the way. I’m not up to fully checking the detail but posting out of interest to others, but with a big warning!

 

So frustrating or maybe interesting if we had more detail on the patients and what they’d done in the lead up

eg to see severity and get a sense of whether any of them were in PEM or were ‘exerted’ just by getting there

or any other things. I guess we can try and pick through methods for detail but long term with these things I’d like to know in case there is a pattern re replication that relates to any of those types of things