Preprint Immunological and Antigenic Signatures Associated with Chronic Illnesses after COVID-19 Vaccination, 2025, Bhattacharjee et al

Abstract
COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the population reports a chronic debilitating condition after COVID-19 vaccination, often referred to as post- vaccination syndrome (PVS). To explore potential pathobiological features associated with PVS, we conducted a decentralized, cross-sectional study involving 42 PVS participants and 22 healthy controls enrolled in the Yale LISTEN study.

Compared with controls, PVS participants exhibited differences in immune profiles, including reduced circulating memory and effector CD4 T cells (type 1 and type 2) and an increase in TNFα+ CD8 T cells. PVS participants also had lower anti-spike antibody titers, primarily due to fewer vaccine doses. Serological evidence of recent Epstein-Barr virus (EBV) reactivation was observed more frequently in PVS participants. Further, individuals with PVS exhibited elevated levels of circulating spike protein compared to healthy controls.

These findings reveal potential immune differences in individuals with PVS that merit further investigation to better understand this condition and inform future research into diagnostic and therapeutic approaches.

Link | PDF (MedRxiv preprint, February 2025, open access)

 

Yale News: 'Immune markers of post vaccination syndrome indicate future research directions'

 

Anti-SARS-CoV-2 antibodies don't seem to be decreasing over time in the post-vaccination syndrome or control groups that had infections, but they do in the PVS group that was not infected.

Edit: I didn't see the very faint controls without infection also in figure 3C. Their antibodies also don't seem to be decreasing with time.

 

Predictably, medicine's massive failure to take the many consequences of COVID seriously has become the biggest boost the conspiracy crowds have ever received. It should almost count as non-monetary donations. They will easily turn this into hundreds of millions.

Of course it does not bother them that LC was happening months before the vaccines, and this is something most of the general public would be able to argue and dismiss if they had been told what is what, but instead the need to cover up is leaving a massive void of credibility and it's being filled by money-grubbing trolls, with the general public having nothing to latch on to.

Alex Jones is one of the biggest conspiracy theorists out there. Huge audience.

And "Died suddenly" is a propaganda film blaming most of the deaths from COVID on the vaccines. It also does not bother them that people were dying long before the vaccines happened. This is why experts need to always tell the truth. They only need to leave one void, make one blatant mistake, and it just gets amplified to all hell. But since most keep doubling down anyway, it's just endless gifts to the grifters.

 

The following has been added to the Declaration of Interests section in a new version:

 

It’s quite unfortunate if this info wasn’t included in previous versions..

 

'No, COVID-19 vaccines don’t suppress your immune system—here's the science'

'A recent preprint filled with fundamental scientific flaws is fueling anti-vaccine disinformation.'

 

Just to highlight this article comes within a hair of calling long covid pseudoscience when it criticises Putrino.

Also, do we see any of these markers the article author names that would need to be present to actually show T Cell exhaustion in the recent Hansen paper? Or in the intramural study?

 

I don't think she makes any claim about anyone's symptoms not being real. She's calling out any unevidenced mechanistic explanations.

What she cites says that symptoms persisting after Lyme are real, but there's little evidence of persistent Lyme bacteria infection.

 

I disagree, I didn’t see anything to hint towards LC being pseudoscientific.

 

Perhaps I misread it. It was the juxtaposition of the psuedoscience comment and the tweet below.

This is the more important question, I think. Would be interested if anyone knows the answer.

 

The Vaccine Discourse Is Broken

Discusses this paper.

https://www.nytimes.com/2025/03/26/...e_code=1.604.VyHI.Vtk4JyFMWKiF&smid=url-share