The problem here is that these are isolated findings over about half a century. People have tried to repeat Simpson's findings and nothing consistent has been reported as far as I know. In addition, we know the clinical presentation of conditions where red cells are stiff or misshapen and it isn't particularly like ME/CFS.
Slow flow in an artificial capillary system does not translate to low oxygenation in any direct way. Ron Davis has put a lot of energy into ME/CFS research but we have not seen any very organised studies over the last ten years and pretty much nothing in the way of formal replicated data.
A few people have noted metabolic shifts but not related to oxygen lack as far as I know - more to do with amino acid usage.
The underlying concern for me is that this 'particular vein of ore' is very much what a lay person without much idea of clinical physiology would go for as plausible. People have been attracted to it for decades. But those who are familiar with muscle physiology don't see it as very plausible after all because it does not add up, in the way I have described. And my old boss Richard Edwards (no relation) had a team of good people put on to muscle in ME/CFS in the 1980s and they found nothing.
I think it is hard for lay people to appreciate just how much medical research is reporting artefacts and irrelevances, particularly in the last 20 years. And if everyone continues to plough on studying these things that don't really add up the likelihood is that they won't scratch their heads and realise that something else might fit. I guess in a way that is what this forum is all about, scratching our heads to see if something else might fit, and keeping on wide-angled spectacles to pick up every bit of information that might just bear on that.
