How seeing his own brain inspired doctor to find a method to rapidly detect delirium

Sly Saint · Dec 15, 2024

As a student, the neurologist Greg Scott had very little interest in following a career in medicine. Computing was the focus of his studies.

Then one day he suffered a grand mal seizure. Also called a tonic-clonic seizure, it causes a loss of consciousness and violent muscle contractions.

“It came out of the blue,” he told the Observer last week. “I was taken to hospital where a scan revealed that I had a brain tumour. It was then removed during an operation during part of which I was completely conscious,” said the researcher at Imperial College London.

“I was later able to watch the operation during a case presentation. So I can say that I have seen my own brain. I was 19 and the experience transformed the trajectory of my career.”

Scott was inspired to study medicine and has put his computational background to good use in his research. “I became fascinated with brain activity and the idea of using AI and other technologies to understand how it generates consciousness and cognition.”

In particular, Scott is concerned with delirium, a common but often misdiagnosed condition that is frequently confused with dementia.

His research, which is funded by the National Institute for Health and Care Research, aims to develop an easy-to-wear device that could rapidly detect if a person is suffering from this debilitating condition.

“Delirium is a massive problem,” said Scott, who is based at Imperial’s UK Dementia Research Institute. “Around 20% of adults in hospitals – around 20,000 NHS patients – are affected by delirium which can be caused by all sorts of different things: the impact of an operation, a urinary tract infection, a chest infection, the side-effects of medication or drug or alcohol misuse.”

The result is confused thinking and a lack of awareness of one’s surroundings, symptoms that can often have a swift onset – sometimes within a few hours. However, to diagnose the condition, clinicians must make subjective decisions.

“We desperately need to find a simple, straightforward objective test that can tell doctors unambiguously within minutes if a person is suffering from delirium – for that could direct them to look for the underlying cause of their condition and allow it to be treated more quickly and effectively,” added Scott.

The key to this work lies with the use of electroencephalograms (EEGs) to record the brain’s electrical activity. Brainwaves were first measured a century ago by the German psychiatrist Hans Berger whose work was received with incredulity and derision when first published. The use of EEGs has since become standard in diagnosing epilepsy and other conditions.
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How seeing his own brain inspired doctor to find a method to rapidly detect delirium

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