Frontiers: The Super-Donor Phenomenon in Fecal Microbiota Transplantation

[Ravn]

This may at least partly explain the patchy results in FMT trials: not all poo is created equal.

Science Alert article: There Are People Amongst Us Whose 'Super Poop' Can Treat Serious Diseases
https://www.sciencealert.com/super-...splants-identified-as-phenomenon-in-new-study

Everybody poops, but some people's excrement is objectively better. Somewhere in the crowd are a few people who pass peerless poops, powerful enough to potentially treat inflammatory bowel disease (IBD) and type 2 diabetes.

A massive analysis of faecal transplant research has now driven these exceptional donors out of the cubicles and into the spotlight.

Frontiers review article: The Super-Donor Phenomenon in Fecal Microbiota Transplantation https://www.frontiersin.org/articles/10.3389/fcimb.2019.00002/full

Fecal microbiota transplantation (FMT) has become a highly effective bacteriotherapy for recurrent Clostridium difficile infection. Meanwhile the efficacy of FMT for treating chronic diseases associated with microbial dysbiosis has so far been modest with a much higher variability in patient response. Notably, a number of studies suggest that FMT success is dependent on the microbial diversity and composition of the stool donor, leading to the proposition of the existence of FMT super-donors. The identification and subsequent characterization of super-donor gut microbiomes will inevitably advance our understanding of the microbial component of chronic diseases and allow for more targeted bacteriotherapy approaches in the future. Here, we review the evidence for super-donors in FMT and explore the concept of keystone species as predictors of FMT success. Possible effects of host-genetics and diet on FMT engraftment and maintenance are also considered. Finally, we discuss the potential long-term applicability of FMT for chronic disease and highlight how super-donors could provide the basis for dysbiosis-matched FMTs.

 

[Lisa108]

The hero we need:

 

[TiredSam]

You called?

 

[Perrier]

You called?

View attachment 5638

Thanks Tired Sam; I sure needed a chuckle today.