Effects of therapeutic interventions on long COVID: a meta-analysis of randomized controlled trials, 2025, Chang Tan et al

Didn't feel like going deeper into the evidence because the included populations were so diverse and dissimilar to ME/CFS.

Also got the impression that the reviewers didn't care much about quality of evidence. Only briefly scanned the studies but of the 25 included I don't think there's one trial that is robust and sound.
Clearly neither does The Lancet or its reviewers.

Which is the bigger problem. Publish this junk in some random blog, where it belongs, and it doesn't matter. In fact there are dozens of those already, and they're all over the place. Even though most of them only include a small fraction of them, since they're so awful. Because the entire premise of medical research is that eminence overrules evidence. It doesn't matter what the evidence actually says, it matters who says it, who believes it, who promotes it. The evidence itself, the outcomes, pretty much don't matter at all.

And the low-quality fraudulent pseudoscience is so popular that even prominent sources keep promoting it. It's all completely abstract to them. It's not about people and how they are affected, everything they do is detached from reality. And the more "inside the house" they are, like with Glasziou, the more they defend the worst of it. Because it's the bulk of it, as very little they do actually works. A profession where the worst promoting the worst seems the best way to get promoted. Hard not to see this as a main reason why this so-called evidence-based medicine delivers almost nothing of value.
 
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I sent a letter to the journal.

Let’s hope they take action for once!

PS. The last two numbers in the reference list appears the in the wrong order.
 
Amazingly, I got the following today from the journal, saying a correction is in process. What exactly it will say is unclear. They also suggested that I resubmit my letter with less inflammatory language if I'd like it to be considered for publication. ]

"Dear Dr Tuller,

Thank you for your notification regarding the issues identified in the published manuscript. We have contacted the authors of the article, and a corrigendum will be published to address these issues.

If we proceed with considering your letter for publication, we kindly ask that you revise the language to align with scientific standards, avoiding accusatory or emotive phrasing. The tone should remain neutral and evidence-based..." Etc--then instructions about resubmitting.
 
The tone should remain neutral and evidence-based...
Like the «evidence-based» statements the editorial team allowed to be published in their journal?

I wonder how they are going to correct the article. It would require a substantial rework to the point the a retraction is probably the only viable option.
 
I wonder how they are going to correct the article. It would require a substantial rework to the point the a retraction is probably the only viable option.
good question. The only really legitimate correction is to refute the initial claims. I am definitely curious as to what they will do. But at least they've acknowledged a problem. That's not that common these days!!!
 
Thank you @dave30th. I hope you will submit a letter for publication by the journal. Even if that does mean you have to write it in their house style and aren't allowed to call the recommendations prepostrous.
Yes, I'm composing a new version without the apparently offensive phrases--even though I consider the statement that the findings are "preposterous" to be "evidence-based."
 
After quite a few months, I received a message yesterday from eClinicalMedicne--they are ready to publish my letter, along with a correction from the authors. (They apologized for the delay, saying they had been understaffed.)

I have no idea what exactly the correction will say, because basically their conclusion that excercise training is effective, based on these data, should be retracted, not just clarified somehow. But we'll see what they come up with.

Of course, I had to remove language they considered offensive, such as "preposterous," despite its appropriateness in this context. But that's ok.
 
Corrigendum to ‘Effects of therapeutic interventions on long COVID: a meta-analysis of randomized controlled trials’

Chang Tana; Jiahao Menga; Xingui Daic; Baimei Hed; Pan Liua; Yumei Wua; Yilin Xionga; Heng Yina; Shuhao Wanga; Shuguang Gaoa

[Line breaks added]

Description of the error and impact on results and conclusion
After the publication of this article, a post-publication review revealed that, due to an oversight during the literature screening process, one reference which did not meet the inclusion criteria was erroneously included in the study.

We sincerely regret this error and have taken corrective measures. The non-compliant reference, “Breathing exercises versus strength exercises through telerehabilitation in coronavirus disease 2019 patients in the acute phase: a randomized controlled trial”,1 has been removed, and the meta-analysis has been re-executed accordingly.

A total of five meta-analyses in exercise training incorporated this erroneous article. Among them, the four outcomes—6MWT, 30sSTS, VAFS, and MBDS—exhibited no change in either the direction of the pooled effect size or its statistical significance. A change in the direction of the pooled effect size was observed for VE (L/min), although this remained non-significant.

These adjustments do not affect the robustness of the article's overall conclusions, nor do they alter its academic value or clinical relevance.

Web | DOI | PDF | eClinicalMedicine | Open Access | 2026
 
well, I guess they published that before my letter. The correction is certainly unsatisfactory, for multiple reasons. My letter did not indicate that this was the only trial that did not meet the criteria; there was at least one other. but the other point was that the trials overall were of low quality, and yet they asserted their final conclusions were solid. which makes no sense.
 
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